CKLF Antibody

Datasheet

Code	CSB-PA656806
Size	US$100
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Image	Western blot analysis of 3T3 lysis using CKLF antibody.. Secondary antibody was diluted at 1:20000
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Product Details
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Target Background

Product Details

Uniprot No.

Q9UBR5

Target Names

CKLF

Alternative Names

CKLF; CKLF1; HSPC224; UNQ410/PRO772; Chemokine-like factor; C32

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of Human C32.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.; has chemotactic response in monocytes, neutrophils and lymphocytes. Binds CCR4.

Gene References into Functions

Data indicate that leukocyte-infiltrate derived chemokine-like factor (CKLF) expression is a candidate biomarker of favorable prognosis. PMID: 27153559
CKLF1 expression was up-regulated in synovim from rheumatoid arthritis and ankylosing spondylitis patients. PMID: 26838743
expression elevated in the skin of keloid patients PMID: 26986142
role in the pathogenesis of psoriasis by promoting the proliferation of microvascular endothelial cells PMID: 25915746
Chemokine-like factor 1 is over-expressed in patients with atopic dermatitis. PMID: 23983609
CKLF1 can induce proliferation and inhibit apoptosis of human vascular smooth muscle cell through the down-regulation of Bax and Caspase-3 and the up-regulation of Bcl-2 expression. PMID: 23253812
The expression of CKLF1 is up-regulated in atherosclerotic plaques. PMID: 20137403
CKLF1-C19 and -C27 can stimulate antigen-presenting capability of dendritic cells PMID: 20392439
CKLF1 could increase the proliferation of human bone marrow hematopoietic progenitor cells and colony formation PMID: 12411060
Results confirm that the secreted peptides of CKLF1, C27 and C19, have functional activation via CCR4. PMID: 18069042
Chemokine-like factor expression is differentially regulated in myoblasts and myotubes and thrombin could be a strong regulator for its expression PMID: 18294340

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Subcellular Location

[Isoform 1]: Secreted.; [Isoform 2]: Membrane; Multi-pass membrane protein.; [Isoform 4]: Membrane; Multi-pass membrane protein.

Protein Families

Chemokine-like factor family

Tissue Specificity

Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skel

Database Links

HGNC: 13253

OMIM: 616074

KEGG: hsa:51192

STRING: 9606.ENSP00000264001

UniGene: Hs.15159

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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