CLCA2 Antibody

1. we found by calcium imaging that CLCA2 moderately enhanced intracellular-store release but dramatically increased store-operated entry of calcium upon cytosolic depletion PMID: 29758025
2. CLCA2 links junctional adhesion molecule EVA1, to cytosolic signaling proteins that modulate proliferation and differentiation. PMID: 26930581
3. CLCA2 expression is higher in squamous cell carcinoma of the lung compared with adenocarcinoma. PMID: 25548429
4. Variants in CLCA2 were associated with an ileal involvement phenotype of Crohn's disease. PMID: 25557950
5. These results strongly suggest that CLCA2 is involved in the p53 tumor suppressor network and has a significant effect on cell migration and invasion. PMID: 22990203
6. hCLCA2 is required for epithelial differentiation, and its loss during tumor progression contributes to metastasis. PMID: 21909135
7. the reduced expression of CLCA2 was frequently observed in various kinds of cancers including prostate cancer PMID: 22431922
8. Expression of hSK4 as well as hCACC-2 and hCACC-3 but not hCACC-1 was demonstrated by reverse transcriptase PCR on native nasal tissues. PMID: 12612194
9. immunohistochemistry clearly demonstrated colocalisation between hCLCA2 and integrin beta4 PMID: 15707651
10. human CLCA2 protein and mRNA expression are elevated during epithelial stratification, suggesting that this protein plays a role in the growth of multi-layered corneal epithelia during both natural development and tissue cultivation. PMID: 16158324
11. Mostly extracellular with only a single transmembrane segment, unlikely to form a channel. PMID: 16873362
12. hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation. PMID: 19654313

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HGNC: 2016

OMIM: 604003

KEGG: hsa:9635

STRING: 9606.ENSP00000359596

UniGene: Hs.241551