CLEC12A Antibody

1. Enumeration of circulating hMICL+ stem cells by flow cytometry can discriminate between myeloproliferative neoplasm phenotypes and holds potential for monitoring disease evolution. PMID: 29427319
2. CLL-1 is a novel prognostic predictor that could be exploited to supplement the current acute myeloid leukemia prognostic risk stratification system. PMID: 28810819
3. The CLEC12A is an effective new candidate with great potential for in vivo Ag delivery into mDCs and pDCs, thereby using the specialized functions and cross-talk capacity of these DC subsets to boost tumor-reactive T cell immunity in cancer patients. PMID: 27566820
4. Due to the absence of CLEC12A on normal haematopoietic stem cells, CLEC12A stem cell immunophenotyping may contribute to diagnosing and monitoring MDS patients and could furthermore add knowledge about disease propagating cells in MDS. PMID: 27612176
5. We propose the hypothesis that decreased expression of CLEC12A is a common denominator in the hyperinflammatory responses observed in Behcet's syndrome and gout. PMID: 25957656
6. Upon CLL1-selective binding of this fusion protein, granulocytes acquire additional TRAIL-mediated cytotoxic activity that, importantly, potentiates antibody-mediated cytotoxicity of clinically used therapeutic antibodies PMID: 25760768
7. We conclude the hMICL/CD123-based MFC assay is a promising MRD tool in AML. PMID: 24152218
8. There is a potential genetic association of CLEC12A with rheumatoid arthritis (RA). Since CLEC12A encodes for the myeloid inhibitory C-type lectin-like receptor that modulates cytokine synthesis, this receptor may contribute to the pathogenesis of RA. PMID: 22341585
9. For production of cytotoxic T cells, transgenic DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
10. MICL is a negative regulator of granulocyte and monocyte function PMID: 14739280
11. the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1] PMID: 15238421
12. Expression cloning identified the antigen recognized as C-type lectin-like molecule-1, a previously undescribed transmembrane glycoprotein PMID: 15548716
13. Dendritic-cell (DC)-associated C-type lectin receptors (CLRs) take up antigens to present to T cells and regulate DC functions. PMID: 16239426
14. human MICL may be involved in the control of myeloid cell activation during inflammation PMID: 16838277
15. CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia PMID: 17609428
16. mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis PMID: 18350551
17. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent PMID: 19494282

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HGNC: 31713

OMIM: 612088

KEGG: hsa:160364

STRING: 9606.ENSP00000347916

UniGene: Hs.190519