CLIC3 Antibody

Code CSB-PA070203
Size US$100
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Product Details

Uniprot No.
Target Names
CLIC3
Alternative Names
CLIC3; Chloride intracellular channel protein 3
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human CLIC3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Can insert into membranes and form chloride ion channels. May participate in cellular growth control.
Gene References into Functions
  1. CLIC3 is also secreted by cancer cells, is abundant in the stromal and tumour compartments of aggressive ovarian cancers and its levels correlate with poor clinical outcome. PMID: 28198360
  2. in malignant pleural mesothelioma, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls PMID: 26445368
  3. CLIC3 controls trafficking of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. PMID: 25015290
  4. results suggest that increased expression of chloride intracellular channel 3 (CLIC3) may play a role in abnormal placental function associated with the human pregnancy disorders fetal growth restrict and pre-eclampsia PMID: 22795578
  5. The structure of the soluble form of CLIC3, is presented. PMID: 20146363
  6. CLIC3 facilitates chloride ion movement and regulates cellular processes associated with the movement of chloride in placental and fetal membrane cells. PMID: 17027078

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Subcellular Location
Nucleus. Membrane; Single-pass membrane protein. Cytoplasm.
Protein Families
Chloride channel CLIC family
Tissue Specificity
Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.
Database Links

HGNC: 2064

OMIM: 606533

KEGG: hsa:9022

STRING: 9606.ENSP00000419378

UniGene: Hs.64746

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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