CLIC3 Antibody

Datasheet

Code	CSB-PA005548GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O95833

Target Names

CLIC3

Alternative Names

CLIC3; Chloride intracellular channel protein 3

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human CLIC3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Can insert into membranes and form chloride ion channels. May participate in cellular growth control.

Gene References into Functions

CLIC3 is also secreted by cancer cells, is abundant in the stromal and tumour compartments of aggressive ovarian cancers and its levels correlate with poor clinical outcome. PMID: 28198360
in malignant pleural mesothelioma, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls PMID: 26445368
CLIC3 controls trafficking of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. PMID: 25015290
results suggest that increased expression of chloride intracellular channel 3 (CLIC3) may play a role in abnormal placental function associated with the human pregnancy disorders fetal growth restrict and pre-eclampsia PMID: 22795578
The structure of the soluble form of CLIC3, is presented. PMID: 20146363
CLIC3 facilitates chloride ion movement and regulates cellular processes associated with the movement of chloride in placental and fetal membrane cells. PMID: 17027078

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Subcellular Location

Nucleus. Membrane; Single-pass membrane protein. Cytoplasm.

Protein Families

Chloride channel CLIC family

Tissue Specificity

Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.

Database Links

HGNC: 2064

OMIM: 606533

KEGG: hsa:9022

STRING: 9606.ENSP00000419378

UniGene: Hs.64746

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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