CLINT1 Antibody

Datasheet

Code	CSB-PA005552LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA005552LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005552LA01HU at dilution of 1:100 Western Blot Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, Rat liver tissue, Mouse liver tissue All lanes: CLINT1 antibody at 2μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 69, 71 kDa Observed band size: 69 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CLINT1 Polyclonal antibody

Uniprot No.

Q14677

Target Names

CLINT1

Alternative Names

Clathrin interacting protein antibody; Clathrin interactor 1 antibody; Clathrin-interacting protein localized in the trans-Golgi region antibody; CLINT 1 antibody; Clint antibody; CLINT1 antibody; ENTH antibody; Enthoprotin antibody; EPN4 antibody; EPN4_HUMAN antibody; Epsin 4 antibody; Epsin related protein antibody; Epsin-4 antibody; Epsin-related protein antibody; EpsinR antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Clathrin interactor 1 protein (1-625AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CLINT1 Antibody (Product code: CSB-PA005552LA01HU) is Non-conjugated. For CLINT1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA005552LB01HU	CLINT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA005552LC01HU	CLINT1 Antibody, FITC conjugated
Biotin	CSB-PA005552LD01HU	CLINT1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:3000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.

Gene References into Functions

Although epsinR has been shown to be a cargo adaptor, the present study indicates that it is an order of magnitude more abundant in CCVs than its known cargo protein, vti1b, suggesting that it may have other functions as well. PMID: 26179914
These results do not support a significant role of GRIA1 or CLINT1 in the development of schizophrenia in the German population. PMID: 21116212
a novel clathrin-associated protein identified through subcellular proteomics; data suggest a role in clathrin-mediated budding on internal membranes PMID: 12213833
might participate in the formation of clathrin-coated vesicles at the level of the trans-Golgi network and remains associated with the vesicles longer than clathrin and adaptors PMID: 12429846
EpsinR is an ENTH domain-containing protein that interacts with AP-1 PMID: 12589059
Our work reveals the existence of clathrin-independent and -dependent transport steps in the retrograde route, and establishes a function for clathrin and epsinR at the endosome-TGN interface. PMID: 15068792
epsinR is an adaptor for vesicle-associated soluble NSF attachment protein receptor PMID: 15371541
Four adjacent markers at the 5' end of the Epsin 4 gene showed significant evidence of linkage disequilibrium with schizophrenia. PMID: 15793701
Results indicate the presence of a locus near the 5' end of Epsin 4 conferring susceptibility to the disease and provide further support for Epsin 4 as an important potential contributor to genetic risk in schizophrenia. PMID: 16402136
characterization of the molecular details governing the sorting of a SNARE into clathrin-coated vesicles, namely the direct recognition of the three-helical bundle H(abc) domain of the mouse SNARE Vti1b by the human clathrin adaptor epsinR PMID: 18033301
Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese. PMID: 18696005
Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population PMID: 18929466

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Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.

Protein Families

Epsin family

Tissue Specificity

Ubiquitously expressed at low to intermediate levels.

Database Links

HGNC: 23186

OMIM: 607265

KEGG: hsa:9685

STRING: 9606.ENSP00000429824

UniGene: Hs.644000

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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