CLINT1 Antibody

Code CSB-PA005552LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA005552LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005552LA01HU at dilution of 1:100

  • Western Blot
    Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, Rat liver tissue, Mouse liver tissue
    All lanes: CLINT1 antibody at 2μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 69, 71 kDa
    Observed band size: 69 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CLINT1 Polyclonal antibody
Uniprot No.
Target Names
CLINT1
Alternative Names
Clathrin interacting protein antibody; Clathrin interactor 1 antibody; Clathrin-interacting protein localized in the trans-Golgi region antibody; CLINT 1 antibody; Clint antibody; CLINT1 antibody; ENTH antibody; Enthoprotin antibody; EPN4 antibody; EPN4_HUMAN antibody; Epsin 4 antibody; Epsin related protein antibody; Epsin-4 antibody; Epsin-related protein antibody; EpsinR antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human Clathrin interactor 1 protein (1-625AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CLINT1 Antibody (Product code: CSB-PA005552LA01HU) is Non-conjugated. For CLINT1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA005552LB01HU CLINT1 Antibody, HRP conjugated ELISA
FITC CSB-PA005552LC01HU CLINT1 Antibody, FITC conjugated
Biotin CSB-PA005552LD01HU CLINT1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:200-1:3000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.
Gene References into Functions
  1. Although epsinR has been shown to be a cargo adaptor, the present study indicates that it is an order of magnitude more abundant in CCVs than its known cargo protein, vti1b, suggesting that it may have other functions as well. PMID: 26179914
  2. These results do not support a significant role of GRIA1 or CLINT1 in the development of schizophrenia in the German population. PMID: 21116212
  3. a novel clathrin-associated protein identified through subcellular proteomics; data suggest a role in clathrin-mediated budding on internal membranes PMID: 12213833
  4. might participate in the formation of clathrin-coated vesicles at the level of the trans-Golgi network and remains associated with the vesicles longer than clathrin and adaptors PMID: 12429846
  5. EpsinR is an ENTH domain-containing protein that interacts with AP-1 PMID: 12589059
  6. Our work reveals the existence of clathrin-independent and -dependent transport steps in the retrograde route, and establishes a function for clathrin and epsinR at the endosome-TGN interface. PMID: 15068792
  7. epsinR is an adaptor for vesicle-associated soluble NSF attachment protein receptor PMID: 15371541
  8. Four adjacent markers at the 5' end of the Epsin 4 gene showed significant evidence of linkage disequilibrium with schizophrenia. PMID: 15793701
  9. Results indicate the presence of a locus near the 5' end of Epsin 4 conferring susceptibility to the disease and provide further support for Epsin 4 as an important potential contributor to genetic risk in schizophrenia. PMID: 16402136
  10. characterization of the molecular details governing the sorting of a SNARE into clathrin-coated vesicles, namely the direct recognition of the three-helical bundle H(abc) domain of the mouse SNARE Vti1b by the human clathrin adaptor epsinR PMID: 18033301
  11. Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese. PMID: 18696005
  12. Variation in the Epsin 4 gene is significantly associated with psychotic disorder in this Latino population PMID: 18929466

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Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.
Protein Families
Epsin family
Tissue Specificity
Ubiquitously expressed at low to intermediate levels.
Database Links

HGNC: 23186

OMIM: 607265

KEGG: hsa:9685

STRING: 9606.ENSP00000429824

UniGene: Hs.644000

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