CLK2 Antibody

Datasheet

Code	CSB-PA005558ESR1HU
Size	US$166
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Image	Western blot All lanes: CLK2 antibody at 5μg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 61, 18, 60 kDa Observed band size: 61 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005558ESR1HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CLK2 Polyclonal antibody

Uniprot No.

P49760

Target Names

CLK2

Alternative Names

CDC like kinase 2 antibody; CDC-like kinase 2 antibody; CLK 2 antibody; CLK kinase antibody; CLK2 antibody; Clk2 Scamp3 antibody; CLK2_HUMAN antibody; Dual specificity protein kinase CLK2 antibody; hCLK 2 antibody; hCLK2 antibody; Tu52 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dual specificity protein kinase CLK2 protein (240-499AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Phosphorylates PAGE4 at several serine and threonine residues and this phosphorylation attenuates the ability of PAGE4 to potentiate the transcriptional activator activity of JUN.

Gene References into Functions

These findings suggest that CLK2 plays a critical role in controlling the cell cycle and survival of glioblastoma PMID: 27050366
Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT)-related genes and a switch to mesenchymal splice variants of several genes. PMID: 25670169
LAMMER/Cdc2-like kinase, represented by Doa and its mammalian homolog CLK2, is a critical and conserved component in the regulatory program of the mitosis-to-meiosis switch PMID: 23376537
AKT activation controls cell survival to ionizing radiation by phosphorylating CLK2, revealing an important regulatory mechanism required for promoting cell survival. PMID: 20682768

Subcellular Location

Nucleus.; [Isoform 1]: Nucleus. Nucleus speckle.; [Isoform 2]: Nucleus speckle.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily

Tissue Specificity

Endothelial cells. Expressed in androgen-dependent prostate cancer cells.

Database Links

HGNC: 2069

OMIM: 602989

KEGG: hsa:1196

STRING: 9606.ENSP00000354856

UniGene: Hs.73986

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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