CNGA2 Antibody

Code CSB-PA102646
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA102646(CNGA2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA102646(CNGA2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
CNGA2
Alternative Names
CNCA antibody; CNCA1 antibody; CNCG2 antibody; CNG 2 antibody; CNG channel alpha 2 antibody; CNG channel alpha-2 antibody; CNG-2 antibody; CNG2 antibody; CNGA 2 antibody; Cnga2 antibody; CNGA2_HUMAN antibody; Cyclic nucleotide gated cation channel 2 antibody; Cyclic nucleotide gated channel alpha 2 antibody; Cyclic nucleotide gated olfactory channel antibody; Cyclic nucleotide-gated cation channel 2 antibody; Cyclic nucleotide-gated channel alpha-2 antibody; Cyclic nucleotide-gated olfactory channel antibody; FLJ46312 antibody; OCNC1 antibody; OCNCa antibody; OCNCALPHA antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human CNGA2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.
Gene References into Functions
  1. The studies findings provides strong support for role of CNGA2 gene with pathogenicity of isolated congenital anosmia in humans. Together, these results indicate that mutations in key olfactory signaling pathway genes are responsible for human disease. PMID: 28572688
  2. Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia. PMID: 25156905
  3. The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel. PMID: 16533895
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA2 subfamily
Database Links

HGNC: 2149

OMIM: 300338

KEGG: hsa:1260

STRING: 9606.ENSP00000328478

UniGene: Hs.447360

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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