CNP Antibody

1. This study showed that the expression of CNPase protein was significantly decreased but increase expression mrna in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
2. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway PMID: 24808540
3. 2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication. PMID: 24260477
4. No Alzheimer disease-associated differences in CNP and DPYSL2 promoter DNA methylation were observed. PMID: 22954668
5. CNP binds to the structural protein Gag and blocks HIV-1 particle assembly after Gag and viral RNA have associated with the plasma membrane. PMID: 23084924
6. Bipolar I disorder and schizophrenia ahare a number of common genetic risk loci and susceptibility genes including the genes coding for 2',3'-cyclic nucleotide 3' phosphodiesterase enzyme. PMID: 23032943
7. Differential CNP expression correlated with mouse model survival, and CNP immunoassay of a large GBM tissue microarray also showed significant differential patient survival PMID: 22589395
8. The characteristic features in both humans and mice with their partial CNP 'loss-of-function' genotype are best described as 'catatonia-depression' syndrome. PMID: 22473874
9. verified the molecular interaction of Nogo-A with 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP), which could act as a conformational stabilizer for the intrinsically unstructured large segment of Amino-Nogo PMID: 19508346
10. crystal structure of 2',3'-cyclic nucleotide 3'-phosphohydrolase PMID: 15502338
11. crystal structure of the catalytic fragment PMID: 15713463
12. reduced CNP expression in the schizophrenic brain is relevant to disease etiology and therefore provide support for the general hypothesis that altered oligodendrocyte function is an etiological factor in schizophrenia. PMID: 16389193
13. The crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution, is determined. PMID: 17150526
14. study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population PMID: 17306456
15. MOBP and CNP protein in the white matter was not altered. PMID: 17964117
16. The effect of rs2070106 genotype on the CNP expression was transcript specific, and that the genotype was not associated with the expression of other oligodendrocyte-related genes. PMID: 18289148
17. This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. PMID: 18496213
18. Almost all multiple sclerosis patients had cerebrospinal fluid IgG directed to isoforms of one of the oligodendroglial molecules, transketolase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, collapsin response mediator protein 2, and tubulin beta4. PMID: 18676363
19. The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population PMID: 19348671
20. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527
21. The larger CNP isoform, CNP2, contains an N-terminal mitochondrial targeting signal and is localized either in the cytoplasm or mitochondria. Mitochondrial localization is regulated by phosphorylation of the targeting signal by PKC. PMID: 16343930
22. CNP interacts with tubulin and promotes microtubule assembly for process outgrowth in oligodendrocytes. PMID: 16103231

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HGNC: 2158

OMIM: 123830

KEGG: hsa:1267

STRING: 9606.ENSP00000377470

UniGene: Hs.273621