CNP Antibody

Datasheet
Code CSB-PA21939A0Rb
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA21939A0Rb at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CNP Polyclonal antibody
Uniprot No. P09543
Target Names CNP
Alternative Names 2'' antibody; 2'3' cyclic nucleotide 3' phosphodiesterase antibody; 3''-cyclic-nucleotide 3''-phosphodiesterase antibody; CN37_HUMAN antibody; CNP 1 antibody; CNP antibody; CNP1 antibody; CNPase antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human 2\',3\'-cyclic-nucleotide 3\'-phosphodiesterase protein (226-415AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Gene References into Functions
  1. This study showed that the expression of CNPase protein was significantly decreased but increase expression mrna in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
  2. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway PMID: 24808540
  3. 2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication. PMID: 24260477
  4. No Alzheimer disease-associated differences in CNP and DPYSL2 promoter DNA methylation were observed. PMID: 22954668
  5. CNP binds to the structural protein Gag and blocks HIV-1 particle assembly after Gag and viral RNA have associated with the plasma membrane. PMID: 23084924
  6. Bipolar I disorder and schizophrenia ahare a number of common genetic risk loci and susceptibility genes including the genes coding for 2',3'-cyclic nucleotide 3' phosphodiesterase enzyme. PMID: 23032943
  7. Differential CNP expression correlated with mouse model survival, and CNP immunoassay of a large GBM tissue microarray also showed significant differential patient survival PMID: 22589395
  8. The characteristic features in both humans and mice with their partial CNP 'loss-of-function' genotype are best described as 'catatonia-depression' syndrome. PMID: 22473874
  9. verified the molecular interaction of Nogo-A with 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP), which could act as a conformational stabilizer for the intrinsically unstructured large segment of Amino-Nogo PMID: 19508346
  10. crystal structure of 2',3'-cyclic nucleotide 3'-phosphohydrolase PMID: 15502338
  11. crystal structure of the catalytic fragment PMID: 15713463
  12. reduced CNP expression in the schizophrenic brain is relevant to disease etiology and therefore provide support for the general hypothesis that altered oligodendrocyte function is an etiological factor in schizophrenia. PMID: 16389193
  13. The crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution, is determined. PMID: 17150526
  14. study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population PMID: 17306456
  15. MOBP and CNP protein in the white matter was not altered. PMID: 17964117
  16. The effect of rs2070106 genotype on the CNP expression was transcript specific, and that the genotype was not associated with the expression of other oligodendrocyte-related genes. PMID: 18289148
  17. This finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population. PMID: 18496213
  18. Almost all multiple sclerosis patients had cerebrospinal fluid IgG directed to isoforms of one of the oligodendroglial molecules, transketolase, 2',3'-cyclic-nucleotide 3'-phosphodiesterase type I, collapsin response mediator protein 2, and tubulin beta4. PMID: 18676363
  19. The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population PMID: 19348671
  20. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia PMID: 19165527
  21. The larger CNP isoform, CNP2, contains an N-terminal mitochondrial targeting signal and is localized either in the cytoplasm or mitochondria. Mitochondrial localization is regulated by phosphorylation of the targeting signal by PKC. PMID: 16343930
  22. CNP interacts with tubulin and promotes microtubule assembly for process outgrowth in oligodendrocytes. PMID: 16103231

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Subcellular Location Membrane, Lipid-anchor, Melanosome
Protein Families 2H phosphoesterase superfamily, CNPase family
Database Links

HGNC: 2158

OMIM: 123830

KEGG: hsa:1267

STRING: 9606.ENSP00000377470

UniGene: Hs.273621

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