CNPY2 Antibody

1. CNPY2 knockout resulted in the significant suppression of MHCC97H cell proliferation, tumor growth, and hemorrhage. PMID: 30415246
2. Overexpression of CNPY2 can activate the AKT/GSK3beta pathway, which leads to the inactivation of GSK-3beta. The inactivation of GSK-3beta increases the level of Snail, and then decreases the expression of E-cadherin to promote EMT. PMID: 29569784
3. CNPY2 can serve as a therapeutic target to promote the effect of chemotherapy in non-small cell lung cancer. PMID: 29864955
4. CNPY2 isoform2 represents as a novel and valuable prognostic indicator for colorectal cancer patients. PMID: 29135454
5. These findings suggested that CNPY2 promoted cancer cell growth in renal cell carcinoma cells through regulating TP53 gene expression. PMID: 28235487
6. CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway PMID: 26835537
7. CNPY2 is a HIF-1alpha-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization. PMID: 25589425
8. Our results are consistent with an important role of FGF21 and Cnpy2/Msap in the regulation of LDLRs in cultured cells. PMID: 22378787
9. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain in fetal and adult brain. PMID: 12826659

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HGNC: 13529

OMIM: 605861

KEGG: hsa:10330

STRING: 9606.ENSP00000273308

UniGene: Hs.8752