COL2A1 Antibody

Datasheet
Code CSB-PA255449
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P02458
Image
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Collagen II antibody.
  • Immunofluorescence analysis of COS7 cells, using Collagen II antibody.
  • Western blot analysis of extracts from COLO205 cells, using Collagen II antibody.
  • Western blot analysis of extracts from 3T3 cells (Lane 2), using Collagen II antiobdy. The lane on the left is treated with synthesized peptide.
Immunogen Synthesized peptide derived from Human Collagen II.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous levels of total Collagen II protein.
Tested Applications ELISA,WB,IHC,IF;WB:1:500-1:3000,IHC:1:50-1:100,IF:1:100-1:500
Relevance Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

Seema K. Tiwari-Woodruff, J. Cell Biol., Apr 2001; 153: 295.
Alexander Gow, J. Neurosci., Aug 2004; 24: 7051 - 7062.
Anne Florin, Endocrinology, Mar 2005; 146: 1532 - 1540.
Shin-ichiro Kitajiri, J. Cell Sci., Oct 2004; 117: 5087 - 5096.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias chondrocalcin; CO2A1; collagen alpha-1 (II); collagen type II alpha 1;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Target Names COL2A1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Involvement in disease Spondyloepiphyseal dysplasia congenital type (SEDC); Spondyloepiphyseal dysplasia, Stanescu type (SEDSTN); Spondyloepimetaphyseal dysplasia, Strudwick type (SEMDSTWK); Achondrogenesis 2 (ACG2); Legg-Calve-Perthes disease (LCPD); Kniest dysplasia (KD); Avascular necrosis of femoral head, primary, 1 (ANFH1); Osteoarthritis with mild chondrodysplasia (OSCDP); Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T); Multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD); Spondyloperipheral dysplasia (SPD); Stickler syndrome 1 (STL1); Stickler syndrome 1 non-syndromic ocular (STL1O); Rhegmatogenous retinal detachment autosomal dominant (DRRD); Czech dysplasia (CZECHD)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Fibrillar collagen family
Tissue Specificity Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte.
Database Links

HGNC: 2200

OMIM: 108300

KEGG: hsa:1280

STRING: 9606.ENSP00000369889

UniGene: Hs.408182

Pathway PI3K-Akt signaling pathway
Focal adhesion

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