COL2A1 Antibody

Datasheet
Code CSB-PA001745
Size US$167
Uniprot No. P02458
Image
  • Western Blot analysis of COLO205 cells using COL2A1 Polyclonal Antibody
  • Western Blot analysis of K562 cells using COL2A1 Polyclonal Antibody
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from the N-terminal region of Human COL2A1.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,IHC,IF,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias COL2A1; Collagen alpha-1(II) chain; Alpha-1 type II collagen
Immunogen Species Homo sapiens (Human)
Target Names COL2A1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Involvement in disease Spondyloepiphyseal dysplasia congenital type (SEDC); Spondyloepiphyseal dysplasia, Stanescu type (SEDSTN); Spondyloepimetaphyseal dysplasia, Strudwick type (SEMDSTWK); Achondrogenesis 2 (ACG2); Legg-Calve-Perthes disease (LCPD); Kniest dysplasia (KD); Avascular necrosis of femoral head, primary, 1 (ANFH1); Osteoarthritis with mild chondrodysplasia (OSCDP); Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T); Multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD); Spondyloperipheral dysplasia (SPD); Stickler syndrome 1 (STL1); Stickler syndrome 1 non-syndromic ocular (STL1O); Rhegmatogenous retinal detachment autosomal dominant (DRRD); Czech dysplasia (CZECHD)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Fibrillar collagen family
Tissue Specificity Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte.
Database Links

HGNC: 2200

OMIM: 108300

KEGG: hsa:1280

STRING: 9606.ENSP00000369889

UniGene: Hs.408182

Pathway PI3K-Akt signaling pathway
Focal adhesion

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