COL4A6 Antibody

Code CSB-PA005747GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
COL4A6
Alternative Names
COL4A6Collagen alpha-6(IV) chain antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human COL4A6
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Gene References into Functions
  1. Mutation in COL4A6 gene is associated with gastric cancer peritoneal carcinomatosis. PMID: 26811494
  2. COL4A6 is associated with X-linked nonsyndromic hearing loss. PMID: 23714752
  3. We showed that TPM2, CLU, and COL4A6 mRNA levels are downregulated in prostate cancer. PMID: 23621580
  4. expression of collagen type IV alpha6 chain in the smooth muscle BM of the gastrointestinal tract is restricted to the esophagus in humans PMID: 20951201
  5. The expression of collagen type IV was significantly decreased in colorectal cancer tissues. PMID: 18782525
  6. Enhanced expression of collagen type IV is associated with liver metastases from gastrointestinal tumours PMID: 15679046
  7. This study showed that in some cases of esophageal squamous cell carcinoma the alpha5/alpha6 (IV) chains are expressed linearly around the cancer cell nests and the alpha5/alpha6 (IV) chain expression is one prognostic factor of ESCC. PMID: 17955302
  8. Type IV collagen alpha6 chain-derived noncollagenous domain 1 (alpha6NC1) is an endogenous inhibitor of angiogenesis and tumor growth. PMID: 18074349
  9. Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix. PMID: 18474427

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Involvement in disease
Deafness, X-linked, 6 (DFNX6)
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Protein Families
Type IV collagen family
Database Links

HGNC: 2208

OMIM: 300914

KEGG: hsa:1288

STRING: 9606.ENSP00000361290

UniGene: Hs.145586

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