COPE Antibody

Datasheet

Code	CSB-PA03669A0Rb
Size	US$166
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Image	Western Blot Positive WB detected in: PC-3 whole cell lysate, HEK293 whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, Hela whole cell lysate, A375 whole cell lysate All lanes: COPE antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 35, 29 kDa Observed band size: 35 kDa Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA03669A0Rb at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) COPE Polyclonal antibody

Uniprot No.

O14579

Target Names

COPE

Alternative Names

1110005D17Rik antibody; Coatomer epsilon subunit antibody; Coatomer protein complex subunit epsilon antibody; Coatomer subunit epsilon antibody; COPE antibody; COPE_HUMAN antibody; Cope1 antibody; Epsilon coat protein antibody; Epsilon COP antibody; Epsilon COP I antibody; Epsilon subunit of coatomer protein complex antibody; Epsilon-coat protein antibody; Epsilon-COP antibody; FLJ13241 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Coatomer subunit epsilon protein (2-308AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The COPE Antibody (Product code: CSB-PA03669A0Rb) is Non-conjugated. For COPE Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA03669B0Rb	COPE Antibody, HRP conjugated	ELISA
FITC	CSB-PA03669C0Rb	COPE Antibody, FITC conjugated
Biotin	CSB-PA03669D0Rb	COPE Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

Gene References into Functions

Ubiquitylation of epsilon-COP by PIRH2; overexpression of the wild type of PIRH2 in prostate cancer cells causes downregulation of the secretion of prostate-specific antigen. PMID: 17721809
Data show that iPLA(1)gamma is a novel membrane transport factor that contributes to a specific Golgi-to-ER retrograde pathway distinct from presently characterized COPI- and Rab6-dependent pathways. PMID: 19632984

Subcellular Location

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

COPE family

Database Links

HGNC: 2234

OMIM: 606942

KEGG: hsa:11316

STRING: 9606.ENSP00000262812

UniGene: Hs.10326

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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