COX17 Antibody

Code CSB-PA619858LA01HU
Size US$166
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  • Western blot
    All lanes: COX17 antibody at 3.5µg/ml + HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 7 kDa
    Observed band size: 7 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA619858LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA619858LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA619858LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) COX17 Polyclonal antibody
Uniprot No.
Target Names
COX17
Alternative Names
COX 17 antibody; COX17 antibody; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) antibody; COX17 cytochrome c oxidase assembly homolog antibody; COX17 homolog cytochrome c oxidase assembly protein antibody; COX17_HUMAN antibody; cytochrome c oxidase assembly protein cox17 homolog antibody; Cytochrome c oxidase copper chaperone antibody; Human homolog of yeast mitochondrial copper recruitment antibody; MGC104397 antibody; MGC117386 antibody; OTTHUMP00000215284 antibody; OTTHUMP00000215285 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cytochrome c oxidase copper chaperone protein (1-63AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The COX17 Antibody (Product code: CSB-PA619858LA01HU) is Non-conjugated. For COX17 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA619858LB01HU COX17 Antibody, HRP conjugated ELISA
FITC CSB-PA619858LC01HU COX17 Antibody, FITC conjugated
Biotin CSB-PA619858LD01HU COX17 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
Gene References into Functions
  1. These results collectively indicate that Cox17 might not participate in the action of these anticancer organoruthenium complexes, and further verify the distinct anticancer mechanism of the organoruthenium(II) complexes from cisplatin. PMID: 27235272
  2. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1) in the cytoplasm were directly observed with in-cell NMR spectroscopy. PMID: 26589182
  3. Data suggest that Cox17 enhances the reactivity of some platinum/organoplatinum antineoplastic drugs but suppresses the reactivity of at least one platinum antineoplastic drug; glutathione modulates binding of platinum/organoplatinum drugs to Cox17. PMID: 26399480
  4. Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective. PMID: 21816817
  5. Data imply that up-regulation of COX17 function and increased cytochrome c oxidase activity are frequent features of lung carcinogenesis. PMID: 14612491
  6. The binding of copper to Cox17 is needed to activate cytochrome c oxidase by Cox17. PMID: 15504366
  7. Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients PMID: 16520371
  8. Cox17 was studied with regard to its expression, purification, and formation of mixed disulfide adducts with sulfhydryl reagents. PMID: 17208454
  9. XAS (X-ray absorption spectroscopy) determined that Cu4Cox17 contains a Cu4S6-type copper-thiolate cluster, which may provide safe storage of an excess of copper ions PMID: 17672825
  10. Cu(I)HCox17(2S-S), i.e., the copper-loaded form of the protein, can transfer simultaneously copper(I) and two electrons to the human cochaperone Sco1 (HSco1) in the oxidized state, i.e., with its metal-binding cysteines forming a disulfide bond. PMID: 18458339
  11. the absence of Cox17 interferes with copper delivery to Cox2, but not to Cox1. PMID: 19393246

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Subcellular Location
Mitochondrion intermembrane space. Cytoplasm.
Protein Families
COX17 family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 2264

OMIM: 604813

KEGG: hsa:10063

STRING: 9606.ENSP00000261070

UniGene: Hs.534383

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