CST5 Antibody

Datasheet

Code	CSB-PA006093LA01HU
Size	US$166
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Image	IHC image of CSB-PA006093LA01HU diluted at 1:500 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CST5 Polyclonal antibody

Uniprot No.

P28325

Target Names

CST5

Alternative Names

CST 5 antibody; CST5 antibody; Cystatin 5 antibody; Cystatin-5 antibody; Cystatin-D antibody; CystatinD antibody; Cysteine proteinase inhibitor antibody; CYTD_HUMAN antibody; MGC71922 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cystatin-D protein (21-142AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CST5 Antibody (Product code: CSB-PA006093LA01HU) is Non-conjugated. For CST5 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA006093LB01HU	CST5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA006093LC01HU	CST5 Antibody, FITC conjugated
Biotin	CSB-PA006093LD01HU	CST5 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.

Gene References into Functions

Results imply CST5 as an important mediator of tumor suppression by p53 in colorectal cancer. PMID: 26158294
These results support an unanticipated role of cystatin D in the cell nucleus, controlling the transcription of specific genes involved in crucial cellular functions, which may mediate its protective action in colon cancer. PMID: 26364852
Compared with its homologues, cystatin D presents an unusual inhibition profile with a preferential inhibition cathepsin S > cathepsin H > cathepsin L and no inhibition of cathepsin B or pig legumain. PMID: 15728581
Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. PMID: 19662683

Subcellular Location

Secreted.

Protein Families

Cystatin family

Tissue Specificity

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric corpus, small intestine, liver, or gall b

Database Links

HGNC: 2477

OMIM: 123858

KEGG: hsa:1473

STRING: 9606.ENSP00000307132

UniGene: Hs.121489

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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