CST7 Antibody

Code CSB-PA006095GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
CST7
Alternative Names
CMAP antibody; CST 7 antibody; Cst7 antibody; Cystatin 7 antibody; cystatin F (leukocystatin) antibody; Cystatin like metastasis associated protein antibody; Cystatin-7 antibody; Cystatin-F antibody; Cystatin-like metastasis-associated protein antibody; Cystatin7 antibody; CystatinF antibody; CYTF_HUMAN antibody; dJ568C11.1 antibody; Leukocystatin antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CST7
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
Gene References into Functions
  1. during monocyte to macrophage differentiation, the endosomal/lysosomal proteolytic activity can be regulated by cystatin F whose expression is under the control of transcriptional factor C/EBP alpha. PMID: 30033148
  2. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells. PMID: 22365146
  3. Transgenic cystatin F is expressed in model mice only during demyelination; in chronic demyelination, remyelinating ability is lost. PMID: 21344476
  4. cystatin F is an intracellular cysteine peptidase inhibitor with readily regulated expression PMID: 12423348
  5. CST7 is secreted, but artificial modification of its C-terminus can induce its endocytic targeting. PMID: 15212960
  6. Cystatin F was not colocalized with cystatin C shich suggests distinct functions for these two cysteine protease inhibitors in U937 cells. PMID: 15752368
  7. analysis of reduction-dependent activation of human cystatin F PMID: 16601115
  8. A latent protease inhibitor which is itself regulated by proteolysis in the endocytic pathway. PMID: 18256700
  9. Data demonstrate the addition of N-linked sugars to an Asn-X-Cys motif in cystatin F and suggest that the mannose 6-phosphate sorting machinery is used to divert cystatin F from the secretory pathway and to mediate its uptake from extracellular pools. PMID: 19192250

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Subcellular Location
Secreted. Cytoplasm.
Protein Families
Cystatin family
Tissue Specificity
Primarily expressed in peripheral blood cells and spleen.
Database Links

HGNC: 2479

OMIM: 603253

KEGG: hsa:8530

STRING: 9606.ENSP00000420384

UniGene: Hs.143212

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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