Cd207 Antibody

Code CSB-PA837695LA01MO
Size US$166
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Cd207 Polyclonal antibody
Uniprot No.
Target Names
Cd207
Alternative Names
Cd207 antibody; Clec4kC-type lectin domain family 4 member K antibody; Langerin antibody; CD antigen CD207 antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse C-type lectin domain family 4 member K protein (63-331AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Cd207 Antibody (Product code: CSB-PA837695LA01MO) is Non-conjugated. For Cd207 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA837695LB01MO Cd207 Antibody, HRP conjugated ELISA
FITC CSB-PA837695LC01MO Cd207 Antibody, FITC conjugated
Biotin CSB-PA837695LD01MO Cd207 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.
Gene References into Functions
  1. Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form. PMID: 29631057
  2. Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent PMID: 27903635
  3. Data show that Candida albicans and Candida tropicalis preferentially localized in (and persisted within) a sub- population of Peyer's patch Langerin-positive dendritic cells. PMID: 26386376
  4. Langerin is expressed by the XCR1(+) "DC1" population of mice. PMID: 25516751
  5. Langerin+ dermal dendritic cells appear to be site- and strain-specific PMID: 24629018
  6. model of epicutaneous ovalbumin sensitization inducing an inflammatory skin resembling atopic dermatitis (AD) to explore the role of CD207 in the pathogenesis of AD PMID: 23117802
  7. Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation. PMID: 22291181
  8. Data demonstrated that CD207(+) CD8alpha(+) thymic DCs do not share a common origin with T cells but originate from intrathymic precursors. PMID: 21630253
  9. The normal corneal epithelium is endowed with CD11c(+) Langerin+ cells that are LCs, whereas the stroma is endowed with a separate population of (non-LC) Langerin+ DCs. PMID: 21482644
  10. Langerhan cells and (Langerin(+)) dermal dendritic cells thus seem to have a redundant function in regulating contact hypersensitivity PMID: 20703247
  11. molecular cloning and expression of Langerin transcripts in dendritic cells PMID: 11978773
  12. Developmentally regulated expression of Langerin isoforms provides a mechanism by which Langerin involvement in antigen uptake and processing could be regulated. PMID: 15191546
  13. CD207 has a role in maintaining Birbeck granules but not in Langerhans cell function PMID: 15601833
  14. Langerin may have an unanticipated role in cell-matrix interactions that modulate LC development, localization, or function PMID: 16557233
  15. CD207 antigens manifest a high degree of colocalization around the nucleus of the Langerhans cells. PMID: 16941665
  16. langerin(+) DCs patrol the dermis in the steady state and migrate to the skin DLNs charged with skin antigens PMID: 18086862
  17. dermal Langerin(+) dendritic cells (DCs) are radiosensitive and display a distinct cell surface phenotype PMID: 18086865
  18. Depletion of langerin(+) cells impaired intestinal IgA Ab responses after Topical transcutaneous immunization PMID: 18354155
  19. Langerin(+) cells do promote T cell responses to skin Ags PMID: 18354196
  20. In a knockin-mouse model of the immune response against Leishmania major parasites, langerin-expressing dendritic cells are, in general, dispensable for an efficient adaptive immune response against L. major parasites. PMID: 19124720
  21. Despite a marginal zone location, CD207(+) DCs lacked identifying molecules for 3 different types of macrophages, localized in proximity and, in contrast to macrophages, marginal zone DCs were poor scavengers of soluble and particulate substrates PMID: 19168629
  22. Langerhans cells(LC) and langerin(+) dermal dendritic cells(DC) represent distinct DC subsets that have specialized functions and that LC are important immunoregulatory cells PMID: 19218433

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Subcellular Location
Membrane; Single-pass type II membrane protein.
Tissue Specificity
Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.
Database Links
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