Cd46 Antibody

Code CSB-PA004939LA01MO
Size US$166
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  • Western Blot
    Positive WB detected in: Mouse skeletal muscle tissue
    All lanes: Cd46 antibody at 4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 41, 34 kDa
    Observed band size: 41 kDa

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004939LA01MO at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Cd46 Polyclonal antibody
Uniprot No.
Target Names
Cd46
Alternative Names
Cd46 antibody; McpMembrane cofactor protein antibody; CD antigen CD46 antibody
Raised in
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant Mouse Membrane cofactor protein (45-329AA)
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated

The Cd46 Antibody (Product code: CSB-PA004939LA01MO) is Non-conjugated. For Cd46 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004939LB01MO Cd46 Antibody, HRP conjugated ELISA
FITC CSB-PA004939LC01MO Cd46 Antibody, FITC conjugated
Biotin CSB-PA004939LD01MO Cd46 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
Gene References into Functions
  1. Changes in CD46 expression may lead to changes in VEGF and play a pathologic role in the development of age-related macular degeneration. PMID: 26161984
  2. Our findings provide evidence for expression of CD46 in the mouse eye and a role for CD46 in protection against laser-induced choroidal neovascularization PMID: 25019227
  3. This fusion is mediated by the interaction between viral glycoproteins expressed on the membrane of the infected cells and CD46 on the glial targets, and is also observed using cells expressing recombinant MV glycoproteins. PMID: 15920733
  4. CD46 isoforms function as receptors for human herpesvirus 6 and measles virus PMID: 12171934
  5. Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm and increased male fertility PMID: 12640142
  6. CD46 has a role as a receptor for fusion and entry of human herpesvirus 6 into target cells PMID: 12724329

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Subcellular Location
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa.; [Isoform 2]: Secreted.
Tissue Specificity
Present only in testis (at protein level).
Database Links
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