Cleaved-EFNA2 (N188) Antibody

Code CSB-PA000043
Size US$100
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  • Western Blot analysis of 293 cells using Cleaved-Ephrin-A2 (N188) Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
EFNA2
Alternative Names
EFNA 2 antibody; efna2 antibody; EFNA2_HUMAN antibody; ELF1 antibody; Eph related receptor tyrosine kinase ligand 6 antibody; EPH-related receptor tyrosine kinase ligand 6 antibody; Ephrin-A2 antibody; EphrinA2 antibody; EPLG6 antibody; HEK7 L antibody; HEK7 ligand antibody; HEK7-L antibody; HEK7L antibody; LERK 6 antibody; LERK-6 antibody; LERK6 antibody; Ligand of eph related kinase 6 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of Human Ephrin-A2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
Gene References into Functions
  1. Ephrin-A2 expression was correlated with Ki-67 expression in PCa patients, both at the gene scale and protein level. Our data indicate that Ephrin-A2 is a potential diagnostic and prognostic biomarker and a promising molecular therapeutic target to attenuate prostate cancer progression PMID: 26561474
  2. these studies suggested that Kaposi's sarcoma-associated herpesvirus utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 mediated signaling involved in its entry PMID: 24550731
  3. High EphA2 receptor expression in colorectal cancer was associated with a worse outcome in patients treated with cetuximab-based therapy PMID: 24050852
  4. Implicate EphA2 as a novel proinflammatory mediator and potential regulator of atherosclerotic plaque development. PMID: 22247258
  5. Optic nerve section in adult rat differentially regulates the expression of ephrin-A2 in the superior colliculus(SC).At 1 month, levels were upregulated across the contralateral SC giving rise to an increasing rostro-caudal gradient. PMID: 11860487
  6. Different forms of Elf-1 are the products of posttranslational modifications that determine its subcellular localization, activity, and metabolic degradation. PMID: 11884456
  7. Abnormal posttranslational mechanisms of the Elf-1 protein result in defective expression of the functional 98-kDa form of Elf-1, and consequently, the transcriptional defect of TCR zeta-chain in patients with systemic lupus erythematosus. PMID: 12421992
  8. There is a significant loss of ELF-1 and reduced Smad4 expression in gastrointestinal neoplasms. PMID: 16158060
  9. Elf-1 represents the first transcription factor identified to be involved in the transcriptional regulation of Fc receptor gamma PMID: 17878388

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families
Ephrin family
Database Links

HGNC: 3222

OMIM: 602756

KEGG: hsa:1943

STRING: 9606.ENSP00000215368

UniGene: Hs.741510

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