DAPK1 Antibody

Datasheet
Code CSB-PA006499ESR1HU
Size US$167

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) DAPK1 Polyclonal antibody
Uniprot No. P53355
Target Names DAPK1
Alternative Names Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1), DAPK1, DAPK
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Death-associated protein kinase 1 protein (1141-1430AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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Target Data

Function Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION
Subcellular Location Isoform 1: Cytoplasm, Cytoplasm, cytoskeleton
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
Tissue Specificity Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas.
Database Links

HGNC: 2674

OMIM: 600831

KEGG: hsa:1612

STRING: 9606.ENSP00000350785

UniGene: Hs.380277

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