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Death-associated protein kinase 1 is a protein in humans that is encoded by DAPK1 gene. Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells.
The following DAPK1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
DAPK1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA006499ESR1HU | DAPK1 Antibody |
Human | ELISA |
| CSB-PA007645 | Phospho-DAPK1 (S308) Antibody |
Human,Mouse | IHC, IF, ELISA |
| CSB-PA007646 | DAPK1 Antibody |
Human,Mouse | WB, IHC, IF, ELISA |
DAPK1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP006499HU CSB-EP006499HU CSB-BP006499HU CSB-MP006499HU CSB-EP006499HU-B |
Recombinant Human Death-associated protein kinase 1 (DAPK1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DAPK1 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP006499MO CSB-EP006499MO CSB-BP006499MO CSB-MP006499MO CSB-EP006499MO-B |
Recombinant Mouse Death-associated protein kinase 1 (Dapk1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DAPK1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E14181h | Human death-associated protein kinase (DAPK) ELISA Kit |
serum, plasma, tissue homogenates, cell lysates | 7.81 pg/mL |
Death-associated protein kinase 1 is a protein in humans that is encoded by the DAPK1 gene. The DAPK1 is a calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. It regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylation of TPM1 by DAPK1 enhances stress fiber formation in endothelial cells.
