DAPK2 Antibody

Code CSB-PA006500GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DAPK2
Alternative Names
DAK2 antibody; DAP kinase 2 antibody; DAP kinase related protein 1 antibody; DAP kinase related protein 1 beta isoform antibody; DAP-kinase-related protein 1 antibody; DAPK2 antibody; DAPK2_HUMAN antibody; Death associated protein kinase 2 antibody; Death-associated protein kinase 2 antibody; DRP 1 antibody; DRP-1 antibody; DRP1 antibody; MGC119312 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human DAPK2-Specific
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytic motility by controlling cell spreading and polarization.; Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
Gene References into Functions
  1. study reveals a unique calmodulin-independent mechanism for DAPK2 activation, critical to its function as a novel downstream effector of AMPK in autophagy PMID: 29717115
  2. This study suggests that miR-520g contributes to tumor progression and drug resistance by post-transcriptionally downregulating DAPK2 in patients with epithelial ovarian cancer PMID: 27049921
  3. Thyroid hormone promotes selective autophagy via induction of DAPK2-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis. PMID: 27653365
  4. miR-520h suppresses Death-associated protein kinase 2 (DAPK2) expression, as restoring DAPK2 abolished miR-520h-promoted drug resistance, and knockdown of DAPK2 mitigated cell death caused by the depletion of miR-520h. PMID: 25982274
  5. that Death-associated protein kinase 2 effector functions are influenced by the protein's subcellular localization PMID: 26483415
  6. This study links adipocyte expression of an autophagy-regulating kinase, lysosome-mediated clearance and fat cell lipid accumulation; it demonstrates obesity-related attenuated autophagy in adipocytes, and identifies DAPK2 dependence in this regulation. PMID: 26038578
  7. DAPK2 is a novel kinase of mTORC1 and is a potential new member of this multiprotein complex, modulating mTORC1 activity and autophagy levels under stress and steady-state conditions. PMID: 25361081
  8. DAPK2 regulates oxidative stress in cancer cells by preserving mitochondrial function PMID: 25741596
  9. DAPK2-induced apoptosis is negatively regulated by Akt and 14-3-3 proteins. PMID: 26047703
  10. DAPK2 is upregulated in uterosacral ligaments in pelvic organ prolapse PMID: 23700042
  11. The defect in chemotaxis in DAPK2-inactive granulocytes is likely a result of reduced polarization of the cells, mediated by a lack of MLC phosphorylation, resulting in radial F-actin and pseudopod formation. PMID: 24163421
  12. The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPalpha during granulocytic differentiation but repressed by PML-RARalpha in APL. PMID: 24038216
  13. DRP-1 and ZIPk most likely evolved from their ancient ancestor gene DAPk by two gene duplication events that occurred close to the emergence of vertebrates PMID: 21408167
  14. Sodium butyrate induced DAPK1/2 expression in human gastric cancer cells and this expression prompted apoptosis by decreasing FAK levels. PMID: 22160140
  15. High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients PMID: 11839660
  16. distinct methylation pattern in bladder cancer with frequent methylation of RARbeta, DAPK, E-cadherin, and p16. PMID: 11839665
  17. gene expression in colorectal and gastric cancer silenced by DNA methylation and histone deacetylation PMID: 12087472
  18. Results implicate a novel role for DAPK2 in the regulation of normal myelopoiesis. PMID: 17347302
  19. DAPK2 as a novel Sp1-dependent target gene for E2F1 and KLF6 in cell death response. PMID: 18521079
  20. beta-catenin-induced down-regulation of DAPk-2 represents a novel signaling mechanism by which beta-catenin promotes the survival of malignant epithelial cells PMID: 18957423

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Subcellular Location
Cytoplasm. Cytoplasmic vesicle, autophagosome lumen.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
Tissue Specificity
Expressed in neutrophils and eosinophils. Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle.
Database Links

HGNC: 2675

OMIM: 616567

KEGG: hsa:23604

STRING: 9606.ENSP00000261891

UniGene: Hs.237886

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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