Product Details

Uniprot No.

Target Names

DBNL

Alternative Names

ABP1 antibody; Actin-binding protein 1 antibody; Cervical mucin associated protein antibody; Cervical mucin-associated protein antibody; Cervical SH3P7 antibody; CMAP antibody; Dbnl antibody; DBNL_HUMAN antibody; Drebrin F antibody; drebrin like antibody; Drebrin like protein antibody; Drebrin-F antibody; Drebrin-like protein antibody; HIP 55 antibody; HIP-55 antibody; HPK1 interacting protein of 55 kDa antibody; HPK1-interacting protein of 55 kDa antibody; SH3 domain containing protein 7 antibody; SH3 domain-containing protein 7 antibody; SH3P7 antibody; src homology 3 domain containing protein HIP 55 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human DBNL

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Gene References into Functions

findings show that mAbp1 and FHL2 are novel binding partners that differentially regulate Rho GTPase signaling and MTLn3 breast cancer cell invasion PMID: 27129278
Data suggest that by binding to both clathrin and F-actin, mammalian actin-binding protein 1 (mAbp1; HIP-55 or SH3P7) is specifically recruited at a late stage of clathrin-coated pits (CCPs) formation, which subsequently recruits dynamin to CCPs. PMID: 25690657
The results presented here indicate that targeting IL-1alpha with subcutaneous MABp1 adminisration has a strong potential therapeutic value in treating psoriasis and may provide a novel future treatment of this often devastating disease. PMID: 25715176
Data indicate that fourteen phosphorylation sites along the primary structure of hematopoietic progenitor kinase 1 (HPK1)-interacting protein of 55 kDa (HIP-55) rotein were identified. PMID: 24651461
HIP-55 expression promoted proliferation, colony formation, migration, and invasion of lung cancer cells and was upregulated in lung cancer cell lines and tumor tissues of lung cancer patients PMID: 24912570
Data suggest that HIP-55 could play an important role in the growth and cellular proliferation and HIP-55 dysfunction could be involved in tumorigenesis. PMID: 24668193
mAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN extravasation during inflammation. PMID: 22450813
substrate for caspase cleavage during apoptosis PMID: 11689006
SH3P7 is essential for endocytosis but not lamellipodia formation. PMID: 12565838
HIP-55 plays a functional role in TCR signaling PMID: 14557276
HIP-55 is a key novel component of the immunological synapse that modulates T cell activation by connecting actin cytoskeleton and TCRs to gene activation and endocytic processes PMID: 14729663
HIP-55 has roles in T-cell proliferation, cytokine production, and immune responses PMID: 16055701
unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55 PMID: 17306257
Filamentous actin (F-actin)-binding protein 1 (Abp1/SH3P7/HIP-55) has a profound impact on synaptic organization by making a required functional connection between postsynaptic density components and postsynaptic actin dynamics. PMID: 18829961

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Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Cell junction, synapse. Perikaryon. Cell projection, neuron projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Early endosome. Cell projection, dendrite. Cell junction, synapse, postsynaptic density.

Protein Families

ABP1 family

Database Links

HGNC: 2696

OMIM: 610106

KEGG: hsa:28988

STRING: 9606.ENSP00000417653

UniGene: Hs.436500