DDX3Y Antibody

Code CSB-PA006622GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DDX3Y
Alternative Names
ATP dependent RNA helicase DDX3Y antibody; ATP-dependent RNA helicase DDX3Y antibody; DBY antibody; DDX3Y antibody; DDX3Y_HUMAN antibody; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y linked antibody; DEAD box protein 3 Y chromosomal antibody; DEAD box protein 3 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide Y chromosome antibody; Y-chromosomal antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human DDX3Y
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway.
Gene References into Functions
  1. DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs. PMID: 26456624
  2. results suggest that MSY genes may play an important role in neural differentiation and demonstrate that DDX3Y could play a multifunctional role in neural cell development PMID: 26144214
  3. fetal germ cell DDX3Y protein expression suggests a role in early spermatogonial proliferation PMID: 22466863
  4. We show here the development of a coordinated B and T-cell response to DBY in a recipient of sex mismatched allogeneic hematopoietic stem-cell transplantation. PMID: 21709606
  5. Gene structure of the human DDX3 and chromosome mapping of its related sequences.Its organization was the same as that of the human DBY gene, a closely related sequence present on the Y chromosome. PMID: 11710523
  6. graft-versus-host (GVH) disease after HLA-identical stem cell transplantation is the result of recognition of minor histocompatibility antigens (mHags) by immunocompetent T lymphocytes from recipient origin. PMID: 11929796
  7. coordinated B and T cell immune response to H-Y minor histocompatibility antigen, DBY, after allogeneic transplant PMID: 15096539
  8. Human Y- and X-encoded DEAD box RNA helicase proteins DDX3Y and DDX3X are interchangeable and have an essential function. Ddx3x mRNA was expressed in almost every cell in mouse testis, suggesting that Ddx3x is involved in spermatogenesis PMID: 15383328
  9. The finding that the testicular transcript of DDX3Y is significantly decreased in patients with severe spermatogenenic failure, especially in those presenting maturation arrest, suggests an important role of DDX3Y during spermatogenesis. PMID: 17881721
  10. Expression of DDX3Y is detected in all myeloid and lymphoid leukemic cells that carry an intact Y chromosome. PMID: 18299450

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Involvement in disease
DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia.
Subcellular Location
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
Protein Families
DEAD box helicase family, DDX3/DED1 subfamily
Tissue Specificity
Widely expressed at the mRNA level, with highest levels in testis. Testis-specific (at protein level). Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes.
Database Links

HGNC: 2699

OMIM: 400010

KEGG: hsa:8653

STRING: 9606.ENSP00000336725

UniGene: Hs.99120

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