DGKK Antibody

Code CSB-PA099899
Size US$297
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  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DGKK antibody.
  • Immunofluorescence analysis of COS-7 cells, using DGKK antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DGKK Polyclonal antibody
Uniprot No.
Target Names
DGKK
Alternative Names
DGKKDiacylglycerol kinase kappa antibody; DAG kinase kappa antibody; EC 2.7.1.107 antibody; 142 kDa diacylglycerol kinase antibody; Diglyceride kinase kappa antibody; DGK-kappa antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from C-terminal of Human DGKK.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC,IF
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).
Gene References into Functions
  1. FMRP is mostly associated diacylglycerol kinase kappa (Dgkkappa), a master regulator that controls the switch between diacylglycerol and phosphatidic acid signaling pathways. PMID: 27233938
  2. Dgkk appears to be a marker or mediator of squamous cell differentiation in development of mouse external genitalia. No association exists between Dgkk expression and formation of preputial cleft in the genital tubercle of diethylsilbestrol treated mice. PMID: 26162297
  3. Studied the relationship between DGKK single nucleotide polymorphisms (SNPs) and hypospadias risk in the Han Chinese population. PMID: 25327554
  4. Common variants in DGKK are strongly associated with risk of hypospadias PMID: 21113153
  5. DGK kappa is a novel human type II diacylglycerol kinase PMID: 16210324

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Subcellular Location
Cell membrane; Peripheral membrane protein.
Protein Families
Eukaryotic diacylglycerol kinase family
Tissue Specificity
Expressed in testis, and to a lesser extent in placenta.
Database Links

HGNC: 32395

OMIM: 300837

KEGG: hsa:139189

UniGene: Hs.38132

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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