DGKK Antibody

Code CSB-PA099899
Size US$297Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DGKK antibody.
  • Immunofluorescence analysis of COS-7 cells, using DGKK antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) DGKK Polyclonal antibody
Uniprot No. Q5KSL6
Target Names DGKK
Alternative Names DGKKDiacylglycerol kinase kappa antibody; DAG kinase kappa antibody; EC 2.7.1.107 antibody; 142 kDa diacylglycerol kinase antibody; Diglyceride kinase kappa antibody; DGK-kappa antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from C-terminal of Human DGKK.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,IHC,IF
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
IF 1:100-1:500
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).
Gene References into Functions
  1. FMRP is mostly associated diacylglycerol kinase kappa (Dgkkappa), a master regulator that controls the switch between diacylglycerol and phosphatidic acid signaling pathways. PMID: 27233938
  2. Dgkk appears to be a marker or mediator of squamous cell differentiation in development of mouse external genitalia. No association exists between Dgkk expression and formation of preputial cleft in the genital tubercle of diethylsilbestrol treated mice. PMID: 26162297
  3. Studied the relationship between DGKK single nucleotide polymorphisms (SNPs) and hypospadias risk in the Han Chinese population. PMID: 25327554
  4. Common variants in DGKK are strongly associated with risk of hypospadias PMID: 21113153
  5. DGK kappa is a novel human type II diacylglycerol kinase PMID: 16210324

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Subcellular Location Cell membrane; Peripheral membrane protein.
Protein Families Eukaryotic diacylglycerol kinase family
Tissue Specificity Expressed in testis, and to a lesser extent in placenta.
Database Links

HGNC: 32395

OMIM: 300837

KEGG: hsa:139189

UniGene: Hs.38132

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