DIRAS1 Antibody

Code CSB-PA002151
Size US$167
Image
  • Western Blot analysis of HepG2 cells using Di-Ras1 Polyclonal Antibody
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Product Details

Uniprot No. O95057
Target Names DIRAS1
Alternative Names DIRAS1 antibody; GBTS1 antibody; RIGGTP-binding protein Di-Ras1 antibody; Distinct subgroup of the Ras family member 1 antibody; Ras-related inhibitor of cell growth antibody; Rig antibody; Small GTP-binding tumor suppressor 1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from the C-terminal region of Human Di-Ras1.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Displays low GTPase activity and exists predominantly in the GTP-bound form.
Gene References into Functions
  1. This neuronal DIRAS1 gene with a proposed role in cholinergic transmission provides not only a candidate for human myoclonic epilepsy but also insights into the disease etiology, while establishing a spontaneous model for future intervention studies and functional characterization. PMID: 28223533
  2. Results show that DIRAS1 is frequently methylated in human colorectal cancer and the expression of DIRAS1 is silenced by promoter region methylation. PMID: 28491151
  3. DiRas1 expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS and inhibiting the binding of other small GTPases to SmgGDS PMID: 26814130
  4. DIRAS1 downregulation is associated with esophageal squamous cell carcinoma metastasis. PMID: 23436800
  5. a novel Ras-related protein and potential neural tumor suppressor (RIG) PMID: 12107278

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Subcellular Location Cell membrane, Lipid-anchor, Cytoplasmic side
Protein Families Small GTPase superfamily, Di-Ras family
Tissue Specificity Highly expressed in heart and brain.
Database Links

HGNC: 19127

OMIM: 607862

KEGG: hsa:148252

STRING: 9606.ENSP00000325836

UniGene: Hs.172753

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