DOCK7 Antibody

Datasheet

Code	CSB-PA836266LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Jurkat whole cell lysate All lanes: DOCK7 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 243, 242, 239, 240, 73 kDa Observed band size: 243 kDa Immunofluorescent analysis of HepG2 cells using CSB-PA836266LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DOCK7 Polyclonal antibody

Uniprot No.

Q96N67

Target Names

DOCK7

Alternative Names

DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dedicator of cytokinesis protein 7 protein (1440-1671AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DOCK7 Antibody (Product code: CSB-PA836266LA01HU) is Non-conjugated. For DOCK7 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA836266LB01HU	DOCK7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836266LC01HU	DOCK7 Antibody, FITC conjugated
Biotin	CSB-PA836266LD01HU	DOCK7 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:2000-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3.

Gene References into Functions

these results suggest that the DOCK-ANGPTL3 SNPs and their haplotypes were associated with the angiographic severity to coronary artery atherosclerosis and the risk of coronary artery disease (CAD) and ischemic stroke in the Southern Chinese Han population. PMID: 29454388
Possible inter-locus interactions among the DOCK7, PCSK9 and GALNT2 SNPs were also noted. PMID: 26493351
Differences in lipid profiles between the Jing and Han populations might partially attribute to the DOCK7, PCSK9 and GALNT2 gene polymorphisms and their haplotypes determining different risk for the development of cardiovascular diseases. PMID: 26744084
Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. PMID: 27018747
These observations suggest that loss of DOCK7 function causes a syndromic form of epileptic encephalopathy by affecting multiple neuronal processes. PMID: 24814191
Dock7 mediates serum- and HGF-induced glioblastoma cell invasion. PMID: 24518591
DOCK7 functions as an essential and downstream regulator of RAGE-mediated cellular migration through the formation of dendritic pseudopodia. PMID: 23254359
The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex. PMID: 23718289
Dock7 functions as an intracellular substrate for ErbB2 to promote Schwann cell migration. PMID: 18426980

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Involvement in disease

Epileptic encephalopathy, early infantile, 23 (EIEE23)

Subcellular Location

Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons.

Protein Families

DOCK family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 19190

OMIM: 615730

KEGG: hsa:85440

STRING: 9606.ENSP00000340742

UniGene: Hs.744927

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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