DPEP1 Antibody

Datasheet

Code	CSB-PA007123LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HT-29 whole cell lysate, A549 whole cell lysate, U87 whole cell lysate, Hela whole cell lysate All lanes: DPEP1 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 46 kDa Observed band size: 46 kDa Immunofluorescence staining of HepG2 cells with CSB-PA007123LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DPEP1 Polyclonal antibody

Uniprot No.

P16444

Target Names

DPEP1

Alternative Names

Dehydropeptidase-I antibody; Dipeptidase 1 (renal) antibody; Dipeptidase 1 antibody; DPEP1 antibody; DPEP1_HUMAN antibody; hRDP antibody; MBD1 antibody; MDP antibody; Microsomal dipeptidase antibody; RDP antibody; Renal dipeptidase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dipeptidase 1 protein (23-252AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DPEP1 Antibody (Product code: CSB-PA007123LA01HU) is Non-conjugated. For DPEP1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA007123LB01HU	DPEP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007123LC01HU	DPEP1 Antibody, FITC conjugated
Biotin	CSB-PA007123LD01HU	DPEP1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Antigen Affinity purified & Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics.; Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.

Gene References into Functions

The results suggest that DPEP1 promotes cancer metastasis by regulating E-cadherin plasticity and that it might be a potential therapeutic target for preventing the progression of colon cancer. PMID: 26824987
In this study, we present an analysis of Neanderthal introgression at the dipeptidase 1 gene, DPEP1. PMID: 26392408
Dipeptidase 1 has been identified as an excellent marker of high-grade IEN and CRC, and may thus be applied for screening of early neoplastic lesions and for prognostic stratification. PMID: 23839495
DPEP1 plays a role in pancreatic cancer aggressiveness. PMID: 22363658
DPEP1 is expressed in the early stages of colon carcinogenesis and affects cancer cell invasiveness. PMID: 20824289
we identified a novel immunohistochemical marker, dipeptidase 1, to distinguish primary mucinous ovarian cancers from ovarian metastasis of colorectal cancers. PMID: 21076463
Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis PMID: 12144777
DPEP1 has a role in colorectal carcinoma PMID: 15145522

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Subcellular Location

Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor.

Protein Families

Metallo-dependent hydrolases superfamily, Peptidase M19 family

Tissue Specificity

Expressed in lung and kidneys.

Database Links

HGNC: 3002

OMIM: 179780

KEGG: hsa:1800

STRING: 9606.ENSP00000261615

UniGene: Hs.109

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Service

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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