DPP9 Antibody

Code CSB-PA007143GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
DPP9
Alternative Names
Dipeptidyl peptidase 9 antibody; Dipeptidyl peptidase IV related protein 2 antibody; Dipeptidyl peptidase IV-related protein 2 antibody; Dipeptidyl peptidase IX antibody; Dipeptidyl peptidase like protein 9 antibody; Dipeptidyl peptidase-like protein 9 antibody; Dipeptidylpeptidase 9 antibody; Dipeptidylpeptidase IX antibody; DKFZp762F117 antibody; DP 9 antibody; DP9 antibody; DPLP 9 antibody; DPLP9 antibody; DPP 9 antibody; DPP IX antibody; DPP9 antibody; DPP9_HUMAN antibody; DPRP 2 antibody; DPRP-2 antibody; DPRP2 antibody; FLJ16073 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human DPP9
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.
Gene References into Functions
  1. The data of this study have shown that fibroblasts and keratinocytes of normal skin endogenously express DPP9 both at transcriptional and protein level. It is localized intracellularly, mostly in cytoplasm, whereby the sub-localization within Golgi is very scarce. PMID: 27682012
  2. DPP9 has a role in promoting tumorgenicity, metastasis and the prediction of poor prognosis in non-small cell lung cancer PMID: 27943262
  3. The DPP9 expressing cell model system is a very useful and promising system for investigating the selectivity and associated toxicity of DPP4 inhibitors on DPP9. PMID: 25464020
  4. There was a concomitant decrease in the phosphorylation of focal adhesion kinase and paxillin, indicating that DPP9 knockdown or enzyme inhibition suppressed the associated adhesion signaling pathway, causing impaired cell movement. PMID: 25486458
  5. Whereas DPP9-short is present in the cytosol, DPP9-long localizes preferentially to the nucleus. PMID: 24562348
  6. DPP9 was found in macrophages of carotid atherosclerotic plaque and may play a role in disease progression. PMID: 23608773
  7. DPP9 binds to SUMO1 through a novel SUMO1 interacting motif. PMID: 23152501
  8. residues important for dimer formation and enzymatic activity PMID: 22001206
  9. These findings suggest an important signaling role of DPP9 in the regulation of survival and proliferation pathways. PMID: 21622624
  10. This is the first study to demonstrate the presence of DP9 in chronic lymphocytic leukemia. PMID: 20534982
  11. identification of two forms, their tissue distribution, cytoplasmic localization PMID: 15245913
  12. cells overexpressing DP9 exhibit behavioral changesin the presence of ECM components; these effects were independent of enzyme activity PMID: 16700509
  13. The DPP9 gene is not associated with the occurrence or curve severity of AIS. It is neither a disease-predisposition nor a disease-modifying gene of AIS. PMID: 18940951
  14. results indicate that the biochemical property of DPP9 is very similar to that of DPP8, its homologous protease. DPP9 and DPP8 are likely redundant proteins carrying out overlapping functions in vivo PMID: 19268648
  15. DPP9, a poorly characterized cytoplasmic prolyl-peptidase, is rate-limiting for destruction of proline-containing substrates both in cell extracts and in intact cells PMID: 19667070

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Subcellular Location
[Isoform 1]: Cytoplasm, cytosol.; [Isoform 2]: Nucleus.
Protein Families
Peptidase S9B family, DPPIV subfamily
Tissue Specificity
Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain.
Database Links

HGNC: 18648

OMIM: 608258

KEGG: hsa:91039

STRING: 9606.ENSP00000262960

UniGene: Hs.515081

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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