DTNB Antibody

Datasheet

Code	CSB-PA187891
Size	US$166
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Image	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 823 cells, Primary antibody: CSB-PA187891(DTNB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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Target Background

Product Details

Uniprot No.

O60941

Target Names

DTNB

Alternative Names

Beta dystrobrevin antibody; Beta-dystrobrevin antibody; DTN B antibody; DTN-B antibody; Dtnb antibody; DTNB_HUMAN antibody; Dystrobrevin beta antibody; MGC17163 antibody; MGC57126 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human DTNB

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses.

Gene References into Functions

Data provide new insights into the role of beta-dystrobrevin in the molecular mechanisms underlying neuronal differentiation that could be relevant in the establishment of the cognitive impairment in Duchene muscular dystrophy. PMID: 27223470
beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35 PMID: 20530487
results suggest that dysbindin assembled into BLOC-1 is not a physiological binding partner of the dystrobrevins, likely due to engagement of its dystrobrevin-binding region in interactions with other subunits PMID: 16448387

Subcellular Location

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Basal cell membrane. Cell junction, synapse, postsynapse. Nucleus.

Protein Families

Dystrophin family, Dystrobrevin subfamily

Tissue Specificity

Highly expressed in brain, kidney and pancreas.

Database Links

HGNC: 3058

OMIM: 602415

KEGG: hsa:1838

STRING: 9606.ENSP00000384084

UniGene: Hs.307720

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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