DUSP16 Antibody

1. The crystal structure of JNK1 bound to the catalytic domain of MKP7 at 2.4-A resolution, providing high-resolution structural insight into the FXF-docking interaction, is reported. PMID: 26988444
2. The DUSP16 ablation leads to a G1/S transition arrest, reduced incorporation of 5-bromodeoxyuridine, enhanced senescence-associated beta-galactosidase activity, and formation of senescence-associated heterochromatic foci. PMID: 26381291
3. analysis of the interaction of the MAPK binding domain of DUSP16 with p38alpha PMID: 23926106
4. PPARdelta-mediated messenger RNA stabilization of mitogen-activated protein kinase phosphatase (MKP)-7 was responsible for the GW501516-mediated inhibition of JNK signaling. PMID: 23639976
5. Data indicate that the activities of phosphoprotein phosphatases MKP5 and MKP7 were determined in the system. PMID: 23233447
6. MKP-7, a negative regulator of JNK, regulates VCAM-1 expression in activated endothelial cells through IRF-1 but not GATA6. PMID: 22182512
7. DUSPs 10 and 16 are positive regulators of activation, apparently acting by modulating cross-talk between the p38 and ERK pathways. PMID: 22245064
8. DUSP16 is a new epigenetically regulated determinant of JNK activation in BL. PMID: 20551953
9. MKP-7 down-regulates ERK-dependent gene expression by blocking nuclear accumulation of phospho-ERK. PMID: 20122898
10. context-dependent role for DUSP16 on cell transformation and apoptosis. PMID: 14586399
11. activation of the ERK pathway strongly blocks JNK activation through stabilization of MKP-7 mediated by phosphorylation PMID: 15689616
12. MKP7 binds beta-arrestin 2 via amino acids 394-443 of MKP7, the same region that interacts with JIP-1 PMID: 15888437
13. identification of an intricate SDF-1alpha-induced signaling cascade that involves eNOS, JNK3, and MKP7and enhances endothelial migration PMID: 19307591

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HGNC: 17909

OMIM: 607175

KEGG: hsa:80824

STRING: 9606.ENSP00000228862

UniGene: Hs.536535