EDEM2 Antibody

Datasheet

Code	CSB-PA030228
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9BV94

Target Names

EDEM2

Alternative Names

bA4204.1 antibody; C20orf31 antibody; C20orf49 antibody; EDEM 2 antibody; EDEM2 antibody; EDEM2_HUMAN antibody; ER degradation enhancer mannosidase alpha like 2 antibody; ER degradation enhancing alpha mannosidase like 2 antibody; ER degradation enhancing alpha mannosidase like protein 2 antibody; ER degradation enhancing mannosidase like protein 2 antibody; ER degradation-enhancing alpha-mannosidase-like 2 antibody; FLJ10783 antibody; UNQ573/PRO1135 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of Human EDEM2.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.

Gene References into Functions

EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog PMID: 24910992
Glycoproteins mannose trimming from Man9GlcNAc2 to Man8GlcNAc2 is conducted mainly by EDEM2. PMID: 25092655
Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in endoplasmic reticulum associated degradation. PMID: 15537790
EDEM2 regulates endoplasmic reticulum-associated glycoprotein degradation PMID: 15579471
Degrades misfolded alpha1-antitrypsin in the ER. PMID: 15537790

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Subcellular Location

Endoplasmic reticulum lumen.

Protein Families

Glycosyl hydrolase 47 family

Tissue Specificity

Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.

Database Links

HGNC: 15877

OMIM: 610302

KEGG: hsa:55741

STRING: 9606.ENSP00000363616

UniGene: Hs.720177

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Protein processing in endoplasmic reticulum

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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