EEA1 Antibody

1. This also suggests that this pathway is involved in EEA1-vesicles biogenesis. PMID: 30188634
2. identification of allergic bronchopulmonary aspergillosis -associated variants in EEA that have functional effects on macrophage phagocytosis and phagolysosome acidification of A. fumigatus conidia. PMID: 29547649
3. results suggest a new mechanism in which Rab5 induces a change in flexibility of EEA1, generating an entropic collapse force that pulls the captured vesicle towards the target membrane to initiate docking and membrane fusion PMID: 27556945
4. EEA1 mobility on endosomes is decreased upon stimulation of EGF receptor endocytosis in HeLa cells PMID: 26993163
5. Under the regulation of Rab5, the fused vesicles are targeted to early endosomes and thus deliver the internalized TbetaRI to the caveolin-1 and EEA1 double-positive early endosomes (caveolin-1-positive early endosomes). PMID: 25998683
6. In serum-deprivated HeLa cells with low endocytic activity there two types of EEA1-vesicles: the first one carries the both EEA1 and Rab5 at high levels; the second consists of weakly decorated EEA1-vesicles that can be both Rab5-positive and -negative. PMID: 25711083
7. Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase Rab31-mediated enhancement of ligand-bound EGF receptor (EGFR) endocytic trafficking. PMID: 24644286
8. nuclear uptake of Abeta involves the dynamin-dependent EEA1 and TGF-beta/Smad signaling pathways. PMID: 24491918
9. We therefore propose that the N1072K variant of the EEA1 gene is a candidate mutation for susceptibility to diabetes in the Japanese population. PMID: 23499280
10. EEA1 interacts with Phafin2 and colocolizes with Phafin2 in endosome membrane. PMID: 22816767
11. NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer. PMID: 22915584
12. p97 inhibition causes increased EEA1 self-association at the endosome membrane. PMID: 21556036
13. The knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via the attenuated phosphorylation of Akt, independent of the effects of EEA1. PMID: 21468601
14. crystal structure of Rab5A in complex with the EEA1 C(2)H(2) zinc finger PMID: 20534488
15. activation of p38 MAPK caused a decrease in EEA1 colocalization with phagosomes, arresting maturation into the phagolysosome PMID: 12963735
16. macropinosomes do not mature to late endosomes or fuse with lysosomes. EEA1 continuously mediates homotypic fusion as long as the macropinosomes persist. PMID: 15052657
17. These results suggest that EEA1 is involved in neuronal synaptic vesicle function and axonal transport and growth. EEA1 may undergo calcium-dependent conformational changes that are required for binding to SNAP-25. PMID: 15451443
18. Results describe the geometry of the micelle penetration of the early endosome antigen 1 FYVE domain. PMID: 16331966
19. PIKfyve is distributed in microdomains that are distinct from those occupied by EEA1 and Hrs PMID: 16448788
20. Impairment of internalization of specific glutamate receptors and their subsequent accumulation in the synapse may account for the neurological deficits observed in some patients developing EEA1 autoantibodies. PMID: 17113235
21. results suggest that the local production of PtdIns(3)P implicates the fusion of macropinosomes via EEA1 as well as conventional early endosomes PMID: 17146146

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HGNC: 3185

OMIM: 605070

KEGG: hsa:8411

STRING: 9606.ENSP00000317955

UniGene: Hs.567367