EEF1A1 Antibody

Datasheet
Code CSB-PA007409GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. P68104
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunogen Human EEF1A1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC,IF
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias eukaryotic translation elongation factor 1 alpha 1;EEF1A1;CCS-3;CCS3;EEF-1;EEF1A;EF-Tu;EF1A;FLJ25721;GRAF-1EF;HNGC:16303;LENG7;MGC102687;MGC131894;MGC16224;PTI1;eEF1A-1 ;
Immunogen Species Homo sapiens (Human)
Target Names EEF1A1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes.
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Function This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Subcellular Location Cytoplasm, Nucleus, Nucleus, nucleolus, Cell membrane
Protein Families TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily
Tissue Specificity Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle.
Database Links

HGNC: 3189

OMIM: 130590

KEGG: hsa:1915

STRING: 9606.ENSP00000330054

UniGene: Hs.535192

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