EIF2AK1 Antibody, Biotin conjugated

Code CSB-PA007510LD01HU
Size US$166
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EIF2AK1 Polyclonal antibody
Uniprot No.
Target Names
EIF2AK1
Alternative Names
E2AK1_HUMAN antibody; EC 2.7.11.1 antibody; Eif2ak1 antibody; Eukaryotic translation initiation factor 2 alpha kinase 1 antibody; Eukaryotic translation initiation factor 2-alpha kinase 1 antibody; HCR antibody; Heme controlled repressor antibody; Heme regulated eukaryotic initiation factor eIF 2 alpha kinase antibody; Heme regulated inhibitor antibody; Heme regulated initiation factor 2 alpha kinase antibody; Heme regulated repressor antibody; Heme sensitive initiation factor 2a kinase antibody; Heme-controlled repressor antibody; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase antibody; Heme-regulated inhibitor antibody; Hemin sensitive initiation factor 2 alpha kinase antibody; Hemin-sensitive initiation factor 2-alpha kinase antibody; HRI antibody; KIAA1369 antibody; PRO1362 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 1 protein (1-86AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. It thereby plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also regulate endoplasmic reticulum (ER) stress during acute heme-deficient conditions. Also activates the ISR in response to mitochondrial dysHRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming.
Gene References into Functions
  1. Activation of HRI is mediated by Hsp90 during stress through modulation of the HRI-Hsp90 complex PMID: 30170366
  2. Taken together, these results suggest HRI as a potential therapeutic target for hemoglobinopathies. PMID: 30026227
  3. data suggests that glutamatergic stimulation induces HRI activation by NO to trigger GluN2B expression and this process would be relevant to maintain postsynaptic activity in cortical neurons PMID: 27557499
  4. The antiviral kinase PKR plays a critical role in controlling HCMV replication. PMID: 27974558
  5. structural and functional stability of HRI PMID: 27888007
  6. Infection-associated functions of HRI (an eIF2alpha kinase) are independent of its activity as a regulator of protein synthesis. PMID: 23874749
  7. During lead-stress, the regulation of hHRI mRNA translation is mediated through its 5'-untranslated region (UTR) that interacts with specific trans-acting factors. PMID: 23357686
  8. Dephosphorylation of eIF2alpha, specifically in the cortex, is both correlated with and necessary for normal memory consolidation. PMID: 23392680
  9. eukaryotic initiation factor 2alpha kinase is a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. PMID: 20071449
  10. autophosphorylation of Thr485 is essential for the hyperphosphorylation and activation of HRI and is required for the acquisition of the eIF2alpha kinase activity PMID: 12767237
  11. These data establish for the first time, the possible mechanisms of regulation of hHRI gene expression under normal physiological condition, hemin exposure and stress. PMID: 19133234

Show More

Hide All

Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Tissue Specificity
Expressed predominantly in erythroid cells. Expressed at much lower levels in hepatocytes (at protein level).
Database Links

HGNC: 24921

KEGG: hsa:27102

STRING: 9606.ENSP00000199389

UniGene: Hs.520205

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*