EIF3F Antibody

Code CSB-PA975347
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA975347(EIF3F Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA975347(EIF3F Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse skin tissue, Primary antibody: CSB-PA975347(EIF3F Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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Product Details

Uniprot No.
Target Names
EIF3F
Alternative Names
Deubiquitinating enzyme eIF3f antibody; eIF 3 epsilon antibody; eIF-3-epsilon antibody; eIF3 p47 antibody; eIF3 p47 subunit antibody; eIF3-epsilon antibody; eIF3-p47 antibody; eIF3f antibody; EIF3F_HUMAN antibody; EIF3S5 antibody; EIF3S5; formerly antibody; Eukaryotic translation initiation factor 3 subunit 5 antibody; Eukaryotic translation initiation factor 3 subunit 5; formerly antibody; Eukaryotic translation initiation factor 3 subunit F antibody; eukaryotic translation initiation factor 3; subunit 5 (epsilon; 47kD) antibody; eukaryotic translation initiation factor 3; subunit 5 epsilon; 47kDa antibody; eukaryotic translation initiation factor 3; subunit F antibody; translation initiation factor 3 47 kda subunit antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Fusion protein of Human EIF3F
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:200-1:1000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.; Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
Gene References into Functions
  1. The overexpression of eIF3f suppressed Akt and ERK signaling and subsequently depleted CLU expression. In addition, eIF3F stabilized p53, which increased the expression of p21 and Bax. PMID: 26988917
  2. eIF3f/alpha adrenergic receptor interaction PMID: 26497985
  3. Decreased expression of eukaryotic initiation factor 3f is associated with gastric cancer. PMID: 24678890
  4. eIF3f may play an important role in recurrence. PMID: 24732644
  5. findings established a new mechanism of rRNA decay regulation mediated by hnRNP K/eIF3f and suggest that the tumor suppressive function of eIF3f may link to impaired rRNA degradation and translation PMID: 22457825
  6. catalytically inactive forms of eIF3f as well as shRNAs targeting eIF3f repress Notch activation in a coculture assay, showing that eIF3f is a new positive regulator of the Notch pathway PMID: 21124883
  7. Loss of EIF3F in pancreatic cancer is reported. PMID: 17918192
  8. demonstrated a statistically significant decrease of the eIF3f gene copy number in melanoma compared with normal tissues with a tumor/normal ratio of 0.52 PMID: 18381585
  9. eIF3f specifically interferes with the 3' end processing of HIV-1 mRNAs PMID: 19237569
  10. eIF3f may inhibit translation by increasing the binding to the eIF3 complex during apoptosis. PMID: 19245811
  11. eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). PMID: 19854136

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Subcellular Location
Cytoplasm.
Protein Families
EIF-3 subunit F family
Database Links

HGNC: 3275

OMIM: 603914

KEGG: hsa:8665

STRING: 9606.ENSP00000310040

UniGene: Hs.516023

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