EME1 Antibody

Datasheet

Code	CSB-PA856897LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA856897LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA856897LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EME1 Polyclonal antibody

Uniprot No.

Q96AY2

Target Names

EME1

Alternative Names

6820428D13 antibody; Crossover junction endonuclease EME1 antibody; EC 3.1.22.- antibody; EME1 antibody; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe) antibody; EME1; S. pombe; homolog of; 1 antibody; EME1_HUMAN antibody; essential meiotic endonuclease 1 homolog 1 (S pombe) antibody; Essential Meiotic Endonuclease 1 Homolog 1 antibody; essential meiotic endonuclease 1 homolog 2 antibody; Essential meiotic endonuclease 1; S. pombe; homolog of; 1 antibody; FLJ31364 antibody; hMMS4 antibody; homolog of yeast EME1 endonuclease antibody; MGC106543 antibody; MMS4 antibody; MMS4 homolog antibody; MMS4L antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Crossover junction endonuclease EME1 protein (1-583AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The EME1 Antibody (Product code: CSB-PA856897LA01HU) is Non-conjugated. For EME1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA856897LB01HU	EME1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA856897LC01HU	EME1 Antibody, FITC conjugated
Biotin	CSB-PA856897LD01HU	EME1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.

Gene References into Functions

The data suggest that subnuclear relocalization is relevant for the function of Mus81-Mms4 complex in response to DNA damage and, probably, of the endonucleases that colocalize with it. PMID: 28813668
EME-1 deficiency affects cell cycle progression and promotes DNA rereplication. PMID: 16456034
Low Eme1 levels were more sensitive to the drug than tumors with high levels. PMID: 19267403

Subcellular Location

Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells.

Protein Families

EME1/MMS4 family

Database Links

HGNC: 24965

OMIM: 610885

KEGG: hsa:146956

STRING: 9606.ENSP00000376952

UniGene: Hs.514330

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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