EME1 Antibody

Code CSB-PA856897LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA856897LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA856897LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EME1 Polyclonal antibody
Uniprot No.
Target Names
EME1
Alternative Names
6820428D13 antibody; Crossover junction endonuclease EME1 antibody; EC 3.1.22.- antibody; EME1 antibody; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe) antibody; EME1; S. pombe; homolog of; 1 antibody; EME1_HUMAN antibody; essential meiotic endonuclease 1 homolog 1 (S pombe) antibody; Essential Meiotic Endonuclease 1 Homolog 1 antibody; essential meiotic endonuclease 1 homolog 2 antibody; Essential meiotic endonuclease 1; S. pombe; homolog of; 1 antibody; FLJ31364 antibody; hMMS4 antibody; homolog of yeast EME1 endonuclease antibody; MGC106543 antibody; MMS4 antibody; MMS4 homolog antibody; MMS4L antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Crossover junction endonuclease EME1 protein (1-583AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The EME1 Antibody (Product code: CSB-PA856897LA01HU) is Non-conjugated. For EME1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA856897LB01HU EME1 Antibody, HRP conjugated ELISA
FITC CSB-PA856897LC01HU EME1 Antibody, FITC conjugated
Biotin CSB-PA856897LD01HU EME1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Gene References into Functions
  1. The data suggest that subnuclear relocalization is relevant for the function of Mus81-Mms4 complex in response to DNA damage and, probably, of the endonucleases that colocalize with it. PMID: 28813668
  2. EME-1 deficiency affects cell cycle progression and promotes DNA rereplication. PMID: 16456034
  3. Low Eme1 levels were more sensitive to the drug than tumors with high levels. PMID: 19267403
Subcellular Location
Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells.
Protein Families
EME1/MMS4 family
Database Links

HGNC: 24965

OMIM: 610885

KEGG: hsa:146956

STRING: 9606.ENSP00000376952

UniGene: Hs.514330

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