EML1 Antibody

Code CSB-PA007642GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
EML1
Alternative Names
echinoderm microtubule associated protein like 1 antibody; Echinoderm microtubule-associated protein-like 1 antibody; ELP79 antibody; EMAL1_HUMAN antibody; EMAP antibody; EMAP-1 antibody; EMAPL antibody; Eml1 antibody; FLJ45033 antibody; HuEMAP antibody; HuEMAP-1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human EML1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
Gene References into Functions
  1. a homozygous truncating variant in EML1 is a novel cause of congenital hydrocephalus. PMID: 28556411
  2. We show that the trimerization domain (TD) of EML1 is necessary and sufficient for self-association. The TD is also essential for MT binding; however, this property requires an adjacent basic region. PMID: 25740311
  3. We found EML1 to be mutated in ribbon-like heterotopia in humans PMID: 24859200
  4. determined a 2.6-A crystal structure of the representative approximately 70-kDa core of EML1, revealing an intimately associated pair of beta-propellers, which we term a TAPE (tandem atypical propeller in EMLs) domain PMID: 24706829
Involvement in disease
Band heterotopia (BH)
Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
Protein Families
WD repeat EMAP family
Tissue Specificity
Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes.
Database Links

HGNC: 3330

OMIM: 600348

KEGG: hsa:2009

STRING: 9606.ENSP00000334314

UniGene: Hs.12451

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