EMP2 Antibody

1. It is a biomarker in gliomas and may have use as a molecular target for the diagnosis and treatment of gliomas. PMID: 28887715
2. High EMP2 expression is associated with endometrial cancer. PMID: 28604744
3. Experiments in vitro using human trophoblast cells lines indicate that EMP2 modulates angiogenesis by altering HIF-1alpha expression. The results reveal a novel role for EMP2 in regulating trophoblast function and vascular development in mice and humans, and suggest that it may be a new biomarker for placental insufficiency. PMID: 28295343
4. All studied ERMs and PVR membranes express EMP2. Levels of EMP2 trended higher in all PVR subgroups than in ERMs, especially in inflammatory and traumatic PVR. PMID: 27294805
5. a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population. PMID: 27530449
6. These results support that loss of EMP2 is common, and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma. PMID: 28347228
7. Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). PMID: 26876307
8. EMP2 plays a tumor suppressor role by inducing G2/M cell cycle arrest, suppressing cell viability, proliferation, colony formation/ anchorage-independent cell growth via regulation of G2/M checkpoints in distinct-derived cell lines. PMID: 25940704
9. Loss of EMP2 is associated with nasopharyngeal carcinoma. PMID: 25684502
10. the role of EMP2 in the pathogenesis of GBM a PMID: 24644285
11. We showed that knockdown of EMP2 in podocytes and endothelial cells resulted in an increased amount of CAVEOLIN-1 and decreased cell proliferation, so EMP2 mutations causes a recessive Mendelian form of steroid-sensitive nephrotic syndrome. PMID: 24814193
12. EMP2 was identified as a tumor-suppressor gene in urinary tract urothelial carcinoma. PMID: 23838430
13. support the role of EMP2 in the control of the tumor microenvironment and confirm the cytotoxic effects observed by EMP2 treatment in vivo PMID: 23334331
14. Manipulation of EMP2 levels in endometrial cancer cells regulates the phosphorylation of FAK and Src, and promotes their distribution into lipid raft domains. PMID: 21637765
15. EMP2 is expressed in the majority of ovarian tumors and may be a feasible target in vivo. PMID: 20670949
16. evaluation as candidate gene for Charcot-Marie-Tooth disease type 1C on chromosome 16p PMID: 11713717
17. This protein is expressed in discrete anatomical regions of the eye. PMID: 12710941
18. EMP2 induces alphavbeta3 surface expression. PMID: 16216233
19. These findings identify EMP2 as a candidate host protein involved in infection of Chlamydia muridarum. [EMP-2] PMID: 17544801
20. EMP2 regulates caveolin-1 transcription and more substantially its protein levels. PMID: 17609206
21. Targeting of EMP2 to specific locations under the influence of these steroid hormones may be important for integrating the molecular responses required for implantation competence. PMID: 18400107
22. EMP2 may be a potential pharmacologic target for human endometrial cancer. PMID: 19010852

Show More

Hide All

HGNC: 3334

OMIM: 602334

KEGG: hsa:2013

STRING: 9606.ENSP00000352540

UniGene: Hs.531561