EMP3 Antibody

Datasheet

Code	CSB-PA007650LA01HU
Size	US$166
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Image	Immunofluorescent analysis of Hela cells using CSB-PA007650LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot All lanes: EMP3 antibody at 3µg/ml + Mouse heart tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 19 kDa Observed band size: 19, 31 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EMP3 Polyclonal antibody

Uniprot No.

P54852

Target Names

EMP3

Alternative Names

EMP3; YMP; Epithelial membrane protein 3; EMP-3; Hematopoietic neural membrane protein 1; HNMP-1; Protein YMP

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Epithelial membrane protein 3 protein (25-65AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The EMP3 Antibody (Product code: CSB-PA007650LA01HU) is Non-conjugated. For EMP3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA007650LB01HU	EMP3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA007650LC01HU	EMP3 Antibody, FITC conjugated
Biotin	CSB-PA007650LD01HU	EMP3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The EMP3 polyclonal antibody was generated in rabbits using recombinant human EMP3 protein (25-65aa) as the immunogen and purified to a level greater than 95% using protein G affinity chromatography. This liquid-form antibody has been tested and proven reactive with human and mouse samples, making it suitable for use in a variety of experimental contexts.

Additionally, this EMP3 polyclonal antibody has been tested in ELISA and WB and has demonstrated its efficacy in recognizing and binding to EMP3 protein. The EMP3 polyclonal antibody's function includes the ability to detect, evaluate, and quantify EMP3 protein levels in biological samples.

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Target Background

Function

Probably involved in cell proliferation and cell-cell interactions.

Gene References into Functions

This study identified and validated a three-gene (EMP3, GSX2 and EMILIN3) prognostic signature in Lower-Grade Gliomas. PMID: 29794476
High EMP3 expression is associated with high grade glioma. PMID: 27527869
epithelial membrane protein 3 is a downstream effector of TWIST1/2 in inducing epithelial-to-mesenchymal transition in gastric cancer. Epithelial membrane protein 3 upregulation might be associated with gastric cancer metastasis and is a potential indicator of unfavorable overall survival and progression-free survival in gastric cancer patients PMID: 28718375
Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy. PMID: 27801851
The study provided a new insight into EMP3, suggesting that EMP3 enhances malignancy of hepatocellular carcinoma cells PMID: 26472188
EMP3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. PMID: 26398721
The aim of this study was to investigate the EMP3 promoter hypermethylation status in a series of 229 astrocytic and oligodendroglial tumors and in 16 glioblastoma cell lines. PMID: 24083241
Decreased expression of EMP3 by promoter methylation is associated by lung cancer PMID: 23920144
LOH 19q determines the complete loss of EMP3 function, as the conserved allele is frequently hypermethylated, and this may represent the molecular basis of the higher risk of relapse in this subgroup of grade II oligodendroglioma patients. PMID: 22992787
The promoter methylation and mRNA expressions of EMP3 and PCDH-gamma-A11 are closely related with the malignant development of glioma. PMID: 20388442
EMP3 overexpression is associated with oligodendroglial tumors PMID: 17187361
Oligodendroglial and astrocytic gliomas show EMP3 hypermethylation and aberrant expression. Primary and secondary glioblastomas have distinct genetic profiles and also differ in their epigenetic aberrations. PMID: 17610521
Loss of EMP3 is associated with esophageal squamous cell carcinoma. PMID: 18823699
Epithelial membrane protein 3 overexpression in breast carcinomas was significantly related to histological grade III , lymph node metastasis , and strong Her-2 expression. PMID: 19270820

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

PMP-22/EMP/MP20 family

Database Links

HGNC: 3335

OMIM: 602335

KEGG: hsa:2014

STRING: 9606.ENSP00000270221

UniGene: Hs.9999

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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