ENSA Antibody

Code CSB-PA01704A0Rb
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA01704A0Rb at dilution of 1:50

  • Immunofluorescent analysis of Hela cells using CSB-PA01704A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ENSA Polyclonal antibody
Uniprot No.
Target Names
ENSA
Alternative Names
ENSAAlpha-endosulfine antibody; ARPP-19e antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Alpha-endosulfine protein (1-121AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ENSA Antibody (Product code: CSB-PA01704A0Rb) is Non-conjugated. For ENSA Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA01704B0Rb ENSA Antibody, HRP conjugated ELISA
FITC CSB-PA01704C0Rb ENSA Antibody, FITC conjugated
Biotin CSB-PA01704D0Rb ENSA Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Gene References into Functions
  1. The extended S phase in Ensa-depleted cells is completely rescued by the overexpression of Treslin. PMID: 28785014
  2. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa/ARPP19 and Cdk substrate dephosphorylation during mitotic exit. PMID: 24391510
  3. Overexpressed ENSA suppresses tumor growth in an established hepatic cell line whereas hypermethylated ENSA might help maintain liver cancer initiating cells. PMID: 24211627
  4. The considerably decreased alpha-endosulfine could result in the continuous opening of K(ATP) channels and the subsequent decrease of neurotransmitters release associated with cognition in Down Syndrome. PMID: 11771735
  5. We mapped ENSA in silico to chromosome 1q21 near a confirmed type 2 diabetes susceptibility locus, and derived the genomic structure of four exons and three introns. PMID: 14728986
  6. The ENSA gene on 1q21 produces several alternatively spliced transcripts, and is located within a region linked with T2DM in diverse populations including the Pima Indians PMID: 14728987

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Subcellular Location
Cytoplasm.
Protein Families
Endosulfine family
Tissue Specificity
Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas.
Database Links

HGNC: 3360

OMIM: 603061

KEGG: hsa:2029

UniGene: Hs.632456

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