EP300 Antibody

Datasheet
Code CSB-PA249150
Former Code(s) CSB-PA790708
Size US$299
Uniprot No. Q09472
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA249150(EP300 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA249150(EP300 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Immunogen Synthetic peptide of Human EP300
Raised in Rabbit
Species Reactivity Human,Mouse
Tested Applications ELISA,IHC;ELISA:1:1000-1:2000,IHC:1:25-1:100
Relevance This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias E1A binding protein p300
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Target Names EP300
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Functions as histone acetyltransferase and regulates transcription via chromatin remodeling
Involvement in disease Rubinstein-Taybi syndrome 2 (RSTS2)
Subcellular Location Cytoplasm, Nucleus, Chromosome
Database Links

HGNC: 3373

OMIM: 602700

KEGG: hsa:2033

STRING: 9606.ENSP00000263253

UniGene: Hs.517517

Pathway cAMP signaling pathway
HIF-1 signaling pathway
Jak-STAT signaling pathway
Melanogenesis
Notch signaling pathway
TGF-beta signaling pathway
Wnt signaling pathway
Cell cycle
FoxO signaling pathway
Glucagon signaling pathway

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