EPN1 Antibody

1. Membrane-proximal domains ENTH of epsin domain can form a stable hexameric core in presence of phosphatidylinositol 4,5-bisphosphate (PIP2). PMID: 29362354
2. Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1. PMID: 26975582
3. intrinsically disordered domains are highly potent drivers of membrane curvature PMID: 26204806
4. AP-2 and epsin-1 are both required to promote efficient internalization of activated PAR1 and recognize discrete receptor sorting signals PMID: 21965661
5. An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations PMID: 12353027
6. Together, these data provide evidence that CHIP functions to ubiquitylate the endocytic protein Epsin. PMID: 15694383
7. epsin 1 promotes endocytosis of the ubiquitinated EGF receptor PMID: 19054389
8. Results show that epsin 1, an endocytic adapter protein, regulates mitotic membrane morphology and spindle integrity in HeLa cells. PMID: 19704019

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HGNC: 21604

OMIM: 607262

KEGG: hsa:29924

UniGene: Hs.279953