EPN1 Antibody

Datasheet

Code	CSB-PA002387
Size	US$100
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Image	Western Blot analysis of MOuse-brain cells using Epsin 1 Polyclonal Antibody Western Blot analysis of K562 cells using Epsin 1 Polyclonal Antibody
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Product Details
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Target Background

Product Details

Uniprot No.

Q9Y6I3

Target Names

EPN1

Alternative Names

EH domain binding mitotic phosphoprotein antibody; EH domain-binding mitotic phosphoprotein antibody; EPN 1 antibody; Epn1 antibody; EPN1_HUMAN antibody; EPS 15 interacting protein 1 antibody; EPS-15-interacting protein 1 antibody; Epsin 1 antibody; Epsin-1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human Epsin 1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis.

Gene References into Functions

Membrane-proximal domains ENTH of epsin domain can form a stable hexameric core in presence of phosphatidylinositol 4,5-bisphosphate (PIP2). PMID: 29362354
Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1. PMID: 26975582
intrinsically disordered domains are highly potent drivers of membrane curvature PMID: 26204806
AP-2 and epsin-1 are both required to promote efficient internalization of activated PAR1 and recognize discrete receptor sorting signals PMID: 21965661
An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations PMID: 12353027
Together, these data provide evidence that CHIP functions to ubiquitylate the endocytic protein Epsin. PMID: 15694383
epsin 1 promotes endocytosis of the ubiquitinated EGF receptor PMID: 19054389
Results show that epsin 1, an endocytic adapter protein, regulates mitotic membrane morphology and spindle integrity in HeLa cells. PMID: 19704019

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Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit.

Protein Families

Epsin family

Database Links

HGNC: 21604

OMIM: 607262

KEGG: hsa:29924

UniGene: Hs.279953

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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