EPN1

EPN1 encodes the protein epsin 1. Also known as Eps15 - interacting protein 1, this protein is involved in the process of clathrin - mediated endocytosis. It functions by binding to phosphatidylinositol 4,5 - bisphosphate on the plasma membrane, which is crucial for the formation of clathrin - coated vesicles. Epsin 1 participates in the Wnt signaling pathway, helping regulate cell proliferation and differentiation.
Mutations or abnormal expression of EPN1 have been associated with certain neurodegenerative diseases. In drug development, targeting EPN1 - related pathways is being explored as a potential strategy for treating these disorders. Although no specific drugs have been approved yet, pre - clinical studies show promise for future therapeutic applications.