ETFB Antibody

Datasheet

Code	CSB-PA267720
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA267720(ETFB Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA267720(ETFB Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LoVo cells, Hela cells, Primary antibody: CSB-PA267720(ETFB Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

P38117

Target Names

ETFB

Alternative Names

Beta ETF antibody; Beta-ETF antibody; Electron transfer flavoprotein beta polypeptide antibody; Electron transfer flavoprotein beta subunit antibody; Electron transfer flavoprotein subunit beta antibody; Electron transferring flavoprotein beta polypeptide antibody; etfB antibody; ETFB_HUMAN antibody; FP585 antibody; MADD antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human ETFB

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.

Gene References into Functions

We identified and replicated a novel gene, ETFB, strongly associated with chronic anthracycline-induced cardiotoxicity independently of age at tumor onset and related to anthracycline-mediated mitochondrial dysfunction PMID: 28913729
These results suggested that increasing levels of ATP5B and ETFB were associated with worsening renal injury. PMID: 27840937
the findings of our present study suggest that ETFbeta plays an important role in renal tubular cell apoptosis during the progression of DN. PMID: 27035869
Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behcet's Disease PMID: 25915519
Human METTL20 is a mitochondrial lysine methyltransferase that targets ETFbeta and modulates its activity. PMID: 25416781
ETFB knockdown can affect TGF-beta-induced tissue remodeling and/or fibrotic processes in vitro. PMID: 23068445
Point mutations in electron-transfer-flavoprotein beta is associated with destabilized conformations and defective protein:protein interactions leading to mitochondrial dysfunction. PMID: 22588007
ETFB participates in the mechanoregulation of fibroblast cell number in collagen gel culture. PMID: 21903359
non-productive conformation stabilization underpins rapid electron transfer to electron-transferring flavoprotein PMID: 15975918
Tissue samples from 16 unrelated patients with ETF deficiency were analysed, two of them harboured mutations in the ETFB gene. PMID: 16510302
conformational and stability properties of the disease-causing variant ETFbeta-D128N, and our findings on the effect of flavinylation in modulating protein conformational stability and activity. PMID: 19088074

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Involvement in disease

Glutaric aciduria 2B (GA2B)

Subcellular Location

Mitochondrion matrix.

Protein Families

ETF beta-subunit/FixA family

Tissue Specificity

Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.

Database Links

HGNC: 3482

OMIM: 130410

KEGG: hsa:2109

STRING: 9606.ENSP00000346173

UniGene: Hs.348531

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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