ETFB Antibody

Code CSB-PA007845GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
ETFB
Alternative Names
Beta ETF antibody; Beta-ETF antibody; Electron transfer flavoprotein beta polypeptide antibody; Electron transfer flavoprotein beta subunit antibody; Electron transfer flavoprotein subunit beta antibody; Electron transferring flavoprotein beta polypeptide antibody; etfB antibody; ETFB_HUMAN antibody; FP585 antibody; MADD antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human ETFB
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.
Gene References into Functions
  1. We identified and replicated a novel gene, ETFB, strongly associated with chronic anthracycline-induced cardiotoxicity independently of age at tumor onset and related to anthracycline-mediated mitochondrial dysfunction PMID: 28913729
  2. These results suggested that increasing levels of ATP5B and ETFB were associated with worsening renal injury. PMID: 27840937
  3. the findings of our present study suggest that ETFbeta plays an important role in renal tubular cell apoptosis during the progression of DN. PMID: 27035869
  4. Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behcet's Disease PMID: 25915519
  5. Human METTL20 is a mitochondrial lysine methyltransferase that targets ETFbeta and modulates its activity. PMID: 25416781
  6. ETFB knockdown can affect TGF-beta-induced tissue remodeling and/or fibrotic processes in vitro. PMID: 23068445
  7. Point mutations in electron-transfer-flavoprotein beta is associated with destabilized conformations and defective protein:protein interactions leading to mitochondrial dysfunction. PMID: 22588007
  8. ETFB participates in the mechanoregulation of fibroblast cell number in collagen gel culture. PMID: 21903359
  9. non-productive conformation stabilization underpins rapid electron transfer to electron-transferring flavoprotein PMID: 15975918
  10. Tissue samples from 16 unrelated patients with ETF deficiency were analysed, two of them harboured mutations in the ETFB gene. PMID: 16510302
  11. conformational and stability properties of the disease-causing variant ETFbeta-D128N, and our findings on the effect of flavinylation in modulating protein conformational stability and activity. PMID: 19088074

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Involvement in disease
Glutaric aciduria 2B (GA2B)
Subcellular Location
Mitochondrion matrix.
Protein Families
ETF beta-subunit/FixA family
Tissue Specificity
Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.
Database Links

HGNC: 3482

OMIM: 130410

KEGG: hsa:2109

STRING: 9606.ENSP00000346173

UniGene: Hs.348531

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