EXOSC10 Antibody, HRP conjugated

Code CSB-PA007889LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EXOSC10 Polyclonal antibody
Uniprot No.
Target Names
EXOSC10
Alternative Names
Autoantigen PM/Scl 2 antibody; Exosc10 antibody; Exosome component 10 antibody; EXOSX_HUMAN antibody; P100 polymyositis scleroderma overlap syndrome associated autoantigen antibody; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen antibody; p2 antibody; p3 antibody; p4 antibody; PM Scl antibody; PM/Scl 100 antibody; PM/Scl-100 antibody; PMSCL antibody; PMSCL2 antibody; Polymyositis/scleroderma autoantigen 100 kDa antibody; Polymyositis/scleroderma autoantigen 2 100 kDa antibody; Polymyositis/scleroderma autoantigen 2 antibody; RRP6 antibody; Rrp6p antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Exosome component 10 protein (587-762AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA.
Gene References into Functions
  1. Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination PMID: 26612606
  2. EXOSC10 can be modified by SUMOylation and identifies a physiological stress where this regulation is prevalent both in vitro and in vivo. PMID: 26857222
  3. Results show that DGCR8 forms an alternative complex with the RRP6-containing form of the exosome, acts as an adaptor to recruit the exosome to target structured RNAs, and the DGCR8/hRRP6 complex controls the stability of human telomerase RNA. PMID: 26687677
  4. Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR. PMID: 22980978
  5. Systemic sclerosis patients with anti-PM-Scl antibody are younger and significantly more often have limited cutaneous involvement, skeletal muscle disease, pulmonary fibrosis and calcinosis. PMID: 22261302
  6. Saccharomyces cerevisiae Rrp6, and determined the X-ray structure of a human construct containing the exoribonuclease and HRDC domains that retains catalytic activity PMID: 21705430
  7. cloning of a more complete cDNA for PM/Scl-75 encoded 84 additional amino acids at its N terminus and only this longer polypeptide is able to associate with the exosome complex. PMID: 12788944
  8. autoantibodies specific to this antigen also are found in systemic sclerosis PMID: 19103309
  9. Anti-PM/Scl antibodies are common in distinct SSc subsets and are associated with several clinical symptoms PMID: 19220911

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Subcellular Location
Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
Database Links

HGNC: 9138

OMIM: 605960

KEGG: hsa:5394

STRING: 9606.ENSP00000366135

UniGene: Hs.632368

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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