FAIM3 Antibody

Code CSB-PA127416
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA127416(FAIM3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: CSB-PA127416(FAIM3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
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Product Details

Uniprot No.
Target Names
FCMR
Alternative Names
FCMR; FAIM3; TOSO; Fas apoptotic inhibitory molecule 3; IgM Fc fragment receptor; Regulator of Fas-induced apoptosis Toso
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Fusion protein of Human FAIM3
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:20-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Gene References into Functions
  1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia. PMID: 21264533
  2. Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic. PMID: 22675200
  3. Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression. PMID: 21756805
  4. Enhanced levels of both membrane-bound and soluble forms of FcmuR in CLL patients. PMID: 21908424
  5. TOSO/FAIM3 may play a role in immune surveillance and contribute to B cell activation PMID: 21908732
  6. TOSO is overexpressed and correlated with disease progression in chronic lymphocytic leukemia. PMID: 21133733
  7. This review focuses on possible functional consequences of Plasmodium falciparum EMP1 protein interaction with the IgM receptor, including interference with immunologic signaling and clearance mechanisms and blocking of specific antibody binding. PMID: 20410497
  8. These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
  9. enzymatically modified-LDL-generated foam cells are protected from cell death most likely through the expression of TOSO by a FLIP(L) independent mechanism PMID: 17553462
  10. demonstrated a 5.6-fold increase of TOSO protein in circulating CLL cells and lymph nodes PMID: 18434611
  11. association with unmutated IgV(H) and the specific induction of TOSO via the BCR suggest autoreactive BCR signaling as a key mediator of apoptosis resistance in CLL. PMID: 18708628
  12. TOSO as a mediator of resistance to apoptosis in chronic lymphocytic leukemia [review] PMID: 19347734
  13. Although this receptor was initially designated as Fas apoptotic inhibitory molecule 3, or TOSO, our results indicate that FcmuR per se has no inhibitory activity in Fas-mediated apoptosis PMID: 19858324

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Subcellular Location
[Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 3]: Secreted.
Tissue Specificity
Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression det
Database Links

HGNC: 14315

OMIM: 606015

KEGG: hsa:9214

STRING: 9606.ENSP00000356058

UniGene: Hs.58831

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