Recombinant Human Fas apoptotic inhibitory molecule 3(FAIM3)

Code CSB-CF007972HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O60667
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence RILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA
Source in vitro E.coli expression system
Gene Names FCMR
Protein Names Recommended name: Fas apoptotic inhibitory molecule 3 Alternative name(s): Regulator of Fas-induced apoptosis Toso
Expression Region 18-390
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Subcellular Location Isoform 1: Membrane, Single-pass membrane protein, SUBCELLULAR LOCATION: Isoform 3: Secreted
Tissue Specificity Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression det
Database Links

HGNC: 14315

OMIM: 606015

KEGG: hsa:9214

STRING: 9606.ENSP00000356058

UniGene: Hs.58831

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